INT128030

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 7.81
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJA1) Golgi apparatus (GJA1) endoplasmic reticulum (GJA1)
cell-cell signaling (GJA1) cytoplasm (GJA1) signal transducer activity (GJA1)
Anatomy Link Frequency
myometrium 3
uterine 3
astrocytes 2
smooth muscle 1
epithelial cells 1
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 10 99.96 Very High Very High Very High
imagery 13 99.80 Very High Very High Very High
lidocaine 1 98.44 Very High Very High Very High
Central nervous system 16 96.48 Very High Very High Very High
Calcium channel 5 96.32 Very High Very High Very High
Dismenorea 47 93.92 High High
alcohol 1 86.20 High High
antagonist 82 80.68 Quite High
Action potential 9 77.72 Quite High
ischemia 2 64.48 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 6 99.34 Very High Very High Very High
Glioma 15 98.90 Very High Very High Very High
Ovarian Cancer 46 98.76 Very High Very High Very High
Endometriosis (extended) 6 98.22 Very High Very High Very High
Cleidocranial Dysplasia 30 96.76 Very High Very High Very High
Dysmenorrhea 47 93.92 High High
Heart Rate Under Development 2 91.12 High High
Congenital Anomalies 12 90.72 High High
Cancer 140 90.24 High High
Injury 6 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings with antibody directed against total connexin 43 are consistent with the increased expression of connexin 43 in the myometrium around the time of labour although it can also be seen that connexin 43 is also present at times other than labour.
Gene_expression (expression) of connexin 43 in myometrium
1) Confidence 0.75 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.21 Pain Relevance 0.25
We generated stable cell lines expressing enhanced yellow fluorescent protein (eYFP)-tagged human Cx43 constructs encoding wild-type and six eYFP-tagged mutant Cx43 mutants: Y17S, G21R, A40V, F52dup, L90V and I130T.
Gene_expression (expressing) of Cx43
2) Confidence 0.75 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.71 Pain Relevance 0.17
As Cx43 is abundantly expressed in astrocytes, we hypothesized that the mutant Cx43 proteins that produce neurological dysfunction have abnormal functional characteristics in astrocytes.
Gene_expression (expressed) of Cx43 in astrocytes associated with anesthesia
3) Confidence 0.75 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.67 Pain Relevance 0.20
To understand how ODDD-associated mutations affect Cx43 signaling in cells of glial origin, we conducted studies in rat C6 glioma cells, a communication-deficient glial cell line that expresses low levels of Cx43.
Gene_expression (expresses) of Cx43 in glial cell associated with cleidocranial dysplasia and glioma
4) Confidence 0.75 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.72 Pain Relevance 0.17
Detailed studies of GJA1 gene regulation indicate that the family of activator protein-1 transcription factors is critical to determine the level of GJA1 expression in myometrial cells [35,36].
Gene_expression (expression) of GJA1
5) Confidence 0.72 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
A better understanding of the pathways that regulate GJA1 expression and phosphorylation in human myometrium should clarify the role of these proteins during pregnancy and labour.
Gene_expression (expression) of GJA1 in myometrium
6) Confidence 0.72 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.09 Pain Relevance 0.09
Retinoic acid upregulates GJA1 expression in human endometrial and myometrial cells probably through nuclear receptors [37,38].
Gene_expression (expression) of GJA1
7) Confidence 0.72 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
We generated stable cell lines expressing enhanced yellow fluorescent protein (eYFP)-tagged human Cx43 constructs encoding wild-type and six eYFP-tagged mutant Cx43 mutants: Y17S, G21R, A40V, F52dup, L90V and I130T.
Gene_expression (expressing) of Cx43
8) Confidence 0.65 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.72 Pain Relevance 0.17
As Cx43 is abundantly expressed in astrocytes, we hypothesized that the mutant Cx43 proteins that produce neurological dysfunction have abnormal functional characteristics in astrocytes.
Gene_expression (produce) of Cx43 in astrocytes associated with anesthesia
9) Confidence 0.65 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.72 Pain Relevance 0.20
Genetic modification of myoblasts to express the gap junction protein connexin43 decreased arrhythmogenicity in cocultures, suggesting a specific means for increasing the safety (and perhaps the efficacy) of myoblast transplantation in patients.
Gene_expression (express) of gap junction protein in myoblasts
10) Confidence 0.58 Published 2005 Journal Circ. Res. Section Abstract Doc Link 15976318 Disease Relevance 0.36 Pain Relevance 0.18
Although this architecture was less apparent in samples from postmenopausal women, unphosphorylated connexin 43 expressing cells were still identifiable as separate from smooth muscle cells that did not express connexin 43 (data not shown).
Gene_expression (expressing) of connexin 43 in smooth muscle cells
11) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.18 Pain Relevance 0
It is observed that connexin 43 expression is greatly increased at the time of parturition and it has been proposed that this connexin, in the form of gap junctions, leads to the formation of a 'functional syncytium' providing for the coordination of contractions throughout the myometrium [3].
Gene_expression (expression) of connexin 43 in myometrium
12) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
Myometrial smooth myocytes from term uterine biopsies expressed connexin 43 in a punctate pattern typical of gap junctions.
Gene_expression (expressed) of connexin 43 in uterine
13) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
In biopsies taken from non-pregnant pre-menopausal women the smooth muscle bundles showed less hypertrophy making rows of unphosphorylated connexin 43 expressing cells more easily visible (data not shown).
Gene_expression (expressing) of connexin 43 in smooth muscle associated with hypertrophy and endometriosis (extended)
14) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.20 Pain Relevance 0
Immunohistochemistry and electromicroscopy demonstrated that AQP4 deletion resulted in decreased expression of gap junction protein connexin43 (Cx43) [41], that is the main gap-junction protein in astrocytes as well as ependymal cells [77].
Gene_expression (expression) of Cx43 in ependymal cells
15) Confidence 0.58 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.44 Pain Relevance 0
GJA1 (connexin 43) is one of the main structural proteins in myometrial gap junctions; its expression is stimulated by oestradiol and inhibited by progesterone [34].
Gene_expression (expression) of GJA1
16) Confidence 0.55 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
Defects in intercellular communication, including reduced or inappropriate expression of Cx43 has emerged as key factors in ovarian carcinoma progression.
Gene_expression (expression) of Cx43 associated with ovarian cancer
17) Confidence 0.18 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.83 Pain Relevance 0.07
Human ovarian surface epithelial cells exhibit extensive gap junction intercellular communications (GJIC) and expression of different types of connexin (Cx), predominantly Cx43.
Gene_expression (expression) of Cx43 in epithelial cells
18) Confidence 0.16 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.85 Pain Relevance 0.07
The levels of Connexin 43 mRNA expression showed a tendency to increase at labour.
Gene_expression (expression) of Connexin 43 mRNA
19) Confidence 0.06 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1475867 Disease Relevance 0 Pain Relevance 0
The aims of the present study were to investigate syndecan 3 and connexin 43 mRNA expressions and protein distributions in human uterine tissue during normal and prolonged labour.


Spec (investigate) Gene_expression (expressions) of connexin 43 mRNA in uterine
20) Confidence 0.05 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1475867 Disease Relevance 0 Pain Relevance 0

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