INT128041

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) nucleolus (Trib3) nucleus (Trib3)
cytoplasmic membrane-bounded vesicle (Bdnf) enzyme binding (Trib3) kinase activity (Trib3)
Anatomy Link Frequency
neurons 1
Bdnf (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 97.84 Very High Very High Very High
spinothalamic tract 6 97.08 Very High Very High Very High
projection neuron 2 77.96 Quite High
qutenza 2 76.96 Quite High
Spinothalamic tract neurons 1 75.00 Quite High
Glutamate 1 73.44 Quite High
spinothalamic 1 64.80 Quite High
Pain 1 60.52 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 93.50 High High
Pain 1 60.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the spinothalamic tract (STT) is a well-characterized pathway for its role in the transfer and integration of sensory and nociceptive informations, this study in rats aimed to 1) determine whether neurons of the STT pathway express the TrkB receptor, 2) establish the rostrocaudal and laminar distribution of STT-TrkB neurons in the whole spinal cord, and 3) test the potential functionality of TrkB expression in these cells by investigating the ability of BDNF to activate the MAP kinase ERK.
BDNF Spec (investigating) Positive_regulation (activate) of kinase in neurons associated with nociception, spinothalamic tract and spinal cord
1) Confidence 0.10 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.29 Pain Relevance 0.79

General Comments

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