INT128043

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
nucleolus (Trib3) nucleus (Trib3) plasma membrane (Ntrk2)
Anatomy Link Frequency
spinal cord 3
Ntrk2 (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.78 Very High Very High Very High
Pain 1 98.74 Very High Very High Very High
Glutamate 1 92.56 High High
projection neuron 2 84.24 Quite High
spinothalamic tract 6 75.04 Quite High
Spinothalamic tract neurons 1 75.00 Quite High
qutenza 2 25.00 Low Low
spinothalamic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 98.74 Very High Very High Very High
Nociception 4 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (activates) of TrkB in spinal cord Positive_regulation (leading) of Phosphorylation (phosphorylation) of kinase in spinal cord associated with pain and spinal cord
1) Confidence 0.07 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.34 Pain Relevance 0.45

General Comments

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