INT128044

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 1.89
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) extracellular region (Bdnf)
plasma membrane (Ephb1) cytoplasmic membrane-bounded vesicle (Bdnf) cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 2
Bdnf (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinothalamic tract neurons 2 99.68 Very High Very High Very High
nMDA receptor antagonist 1 99.60 Very High Very High Very High
qutenza 4 99.44 Very High Very High Very High
Rostral ventromedial medulla 77 98.00 Very High Very High Very High
Spinal cord 12 97.84 Very High Very High Very High
spinothalamic tract 12 97.08 Very High Very High Very High
Neuropathic pain 16 97.04 Very High Very High Very High
Hyperalgesia 10 96.20 Very High Very High Very High
Inflammation 9 95.68 Very High Very High Very High
nMDA receptor 1 94.80 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 19 97.04 Very High Very High Very High
Hyperalgesia 11 96.20 Very High Very High Very High
INFLAMMATION 9 95.68 Very High Very High Very High
Nociception 12 93.50 High High
Pain 17 90.72 High High
Urological Neuroanatomy 4 87.48 High High
Hypersensitivity 7 84.96 Quite High
Nervous System Injury 53 81.36 Quite High
Injury 4 50.00 Quite Low
Amputation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF has been shown in other systems to activate ERK [44] and a role of released BDNF in the activation of ERK in the RVM seems likely.


BDNF Positive_regulation (activate) of ERK associated with rostral ventromedial medulla
1) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.28 Pain Relevance 1.23
Because the spinothalamic tract (STT) is a well-characterized pathway for its role in the transfer and integration of sensory and nociceptive informations, this study in rats aimed to 1) determine whether neurons of the STT pathway express the TrkB receptor, 2) establish the rostrocaudal and laminar distribution of STT-TrkB neurons in the whole spinal cord, and 3) test the potential functionality of TrkB expression in these cells by investigating the ability of BDNF to activate the MAP kinase ERK.
BDNF Spec (investigating) Positive_regulation (activate) of ERK in neurons associated with nociception, spinothalamic tract and spinal cord
2) Confidence 0.26 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.29 Pain Relevance 0.79
TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons.
brain-derived neurotrophic factor Positive_regulation (activation) of ERK in neurons associated with qutenza and spinothalamic tract neurons
3) Confidence 0.22 Published 2005 Journal J. Comp. Neurol. Section Title Doc Link 15977164 Disease Relevance 0.32 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox