INT128045

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 5.32
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) nucleus (Per1) protein binding transcription factor activity (Per1)
cytoplasm (Per1) signal transducer activity (Per1)
Anatomy Link Frequency
SCN 5
retina 1
brain 1
goblet cell 1
neural 1
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 376 99.84 Very High Very High Very High
GABA receptor 51 99.56 Very High Very High Very High
Inflammation 94 99.44 Very High Very High Very High
gABA 656 98.66 Very High Very High Very High
neuropeptide release 9 98.66 Very High Very High Very High
Hippocampus 18 98.52 Very High Very High Very High
Morphine 34 97.92 Very High Very High Very High
GABAergic 74 97.58 Very High Very High Very High
withdrawal 23 97.12 Very High Very High Very High
dopamine receptor 20 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Synovitis 21 100.00 Very High Very High Very High
Hypoxia 6 100.00 Very High Very High Very High
Hypersensitivity 47 99.80 Very High Very High Very High
Arthritis 49 99.62 Very High Very High Very High
INFLAMMATION 67 99.44 Very High Very High Very High
Ocular Hypertension 6 98.60 Very High Very High Very High
Stroke 6 97.90 Very High Very High Very High
Nicotine Addiction 117 97.56 Very High Very High Very High
Disease 65 97.16 Very High Very High Very High
Pneumonia 11 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mPER1 protein expression level in MD mice was increased between 8:00 and 20:00.
Positive_regulation (increased) of mPER1 protein
1) Confidence 0.69 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.51
Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation.
Positive_regulation (activation) of Per1 in suprachiasmatic nucleus
2) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Title Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.06
Photic resetting of the SCN pacemaker involves induction of the clock genes Period1 (Per1) and Period2 (Per2) and communication among distinct cell populations.
Positive_regulation (induction) of Period1 in SCN
3) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0
Altogether, these results indicate that GRP communicates phase resetting signals within the SCN network via both spike-dependent and spike-independent mechanisms, and that activation of the CREB pathway and Per1 are key steps in mediating downstream events in GRP resetting of SCN neurons.
Positive_regulation (activation) of Per1 in SCN
4) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.07
Photic resetting of the SCN pacemaker involves induction of the clock genes Period1 (Per1) and Period2 (Per2) and communication among distinct cell populations.
Positive_regulation (induction) of Per1 in SCN
5) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0
Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.
Spec (whether) Positive_regulation (activation) of Per1 in SCN
6) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.08
On a molecular level, dopamine mediates acute light induction of the Per1 gene in the mouse retina [68] and resets the Xenopus photoreceptor clock through induction of xPer2 [70,71].
Positive_regulation (induction) of Per1 in retina associated with dopamine
7) Confidence 0.65 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.20 Pain Relevance 0.42
During the 6 h advance phase shift induced in the experiment by Reddy et al., the light onset occurred in the middle of the former night, temporarily inducing Per1 mRNA [6]; however, the phase shift achieved in this experiment was markedly slower than the phase delay response.
Positive_regulation (inducing) of Per1
8) Confidence 0.59 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0.06 Pain Relevance 0
A secondary phosphorylation, which only occurs for Per1, prohibits nuclear entry.
Positive_regulation (occurs) of Per1
9) Confidence 0.59 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0.05
In accordance with this hypothesis, the cyclic accumulation of Per1 or Dbp transcripts under short or long photoperiod is locked to lights on in lung, and to lights off in heart [32].
Positive_regulation (accumulation) of Per1 in heart
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002272 Disease Relevance 0 Pain Relevance 0
PER1 was practically undetectable at ZT8, and accumulated to its maximal level during night around ZT20.
Positive_regulation (accumulated) of PER1
11) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002272 Disease Relevance 0 Pain Relevance 0
Our findings suggest D1 dopamine receptors are key to the action of dopamine on the retinal circadian pacemaker, whereas D2 receptors have been suggested to play a role in light-induced Per gene induction by dopamine [68].
Positive_regulation (induction) of Per associated with dopamine and dopamine receptor
12) Confidence 0.57 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.43
However, we hypothesized that the increase in Per1 might be occurring later in our study.
Positive_regulation (increase) of Per1
13) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0
In vitro GRP application resulted in persistent increases in the spike frequency of Per1::GFP-induced neurons.
Positive_regulation (increases) of Per1 in neurons
14) Confidence 0.49 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.09
Therefore, we harvested SCN tissue from mice one hour after the start of a 30 minute light pulse or sham light pulse, 30 minutes later than in our initial study. qPCR assays of these captures revealed a significant increase in both Per1 (7.0× over dark pulse, 95% confidence interval of 2.8 – 17.8, n = 4 per group) and Per2 (1.9× over dark pulse, 95% confidence interval of 1.1 – 3.4, n = 4 per group) expression after the light pulse as compared to the sham light pulse.


Positive_regulation (increase) of Per1
15) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0
Our data establish that GABAergic regulation is a common mechanism across neural circadian clocks because blockade of GABA receptors in SCN explants also increases Per1::luc rhythmic amplitude [65], and application of GABA resets the phase of spike frequency rhythms in isolated SCN neurons [81].
Positive_regulation (increases) of Per1 in neural associated with gaba, gaba receptor and gabaergic
16) Confidence 0.47 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.08 Pain Relevance 0.62
To determine the mechanisms by which GABA suppressed retinal PER2::LUC expression and rhythmicity, we first quantified Per1, Per2, Clock, and Bmal1 mRNA levels 8 h after 3 mM GABA treatment using quantitative real-time PCR.
Positive_regulation (quantified) of Per1 associated with gaba
17) Confidence 0.47 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.53
Light pulses, which induce smaller phase shifts in old animals than in young, lead to decreased induction of Per1, but not of Per2, in the SCN of old hamsters (Kolker et al., 2003).
Positive_regulation (induction) of Per1
18) Confidence 0.45 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.07 Pain Relevance 0
[The effect of ribozyme specially cleaving per1 mRNA on c-fos mRNA and its expression in hippocampus of morphine addicted mice].
Positive_regulation (cleaving) of per1 mRNA in hippocampus associated with hippocampus and morphine
19) Confidence 0.43 Published 2005 Journal Space Med Med Eng (Beijing) Section Title Doc Link 15977398 Disease Relevance 0 Pain Relevance 0.29
Our results suggest that GABA could, through membrane hyperpolarization and activation of casein kinase, stimulate the degradation of accumulated PER proteins on the falling phase of their rhythm (which roughly corresponds to the night state), acting to remove feedback inhibition on Per transcription and thereby preparing retinal oscillators for transcriptional activation that characterizes the “day” state.
Positive_regulation (accumulated) of PER associated with gaba
20) Confidence 0.41 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.62

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