INT128051

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 2.31
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FGF10) extracellular region (FGF10) plasma membrane (FGF10)
nucleus (FGF10) cell-cell signaling (FGF10)
Anatomy Link Frequency
Fibroblast 4
smooth muscle cell 2
transitional epithelium 2
mesoderm 1
urothelial cell 1
FGF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 415 99.68 Very High Very High Very High
Inflammatory mediators 3 99.48 Very High Very High Very High
Inflammation 7 97.20 Very High Very High Very High
pulpitis 2 95.56 Very High Very High Very High
palliative 1 91.40 High High
midbrain 100 79.44 Quite High
cryotherapy 1 72.40 Quite High
chemokine 11 65.04 Quite High
cytokine 2 60.96 Quite High
agonist 3 46.88 Quite Low
Disease Link Frequency Relevance Heat
Injury 11 100.00 Very High Very High Very High
INFLAMMATION 10 99.48 Very High Very High Very High
Pulpitis 2 95.56 Very High Very High Very High
Urinary Tract Disease 5 93.84 High High
Mucositis 1 89.48 High High
Nervous System Malformation 5 86.60 High High
Stomatitis 6 85.32 High High
Neurodegenerative Disease 35 70.88 Quite High
Cancer 6 67.08 Quite High
Adhesions 3 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites, transitional epithelium and smooth muscle cell bundles, both of which were also the exclusive sites of FGF-10 receptor synthesis.
Gene_expression (Synthesis) of FGF-10 in transitional epithelium
1) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16597614 Disease Relevance 0.18 Pain Relevance 0
Investigational agents are targeting the specific mechanisms of mucosal injury; among the most promising of these is recombinant human keratinocyte growth factor.
Gene_expression (targeting) of keratinocyte growth factor in keratinocyte associated with injury
2) Confidence 0.68 Published 2005 Journal Pharmacotherapy Section Abstract Doc Link 15977916 Disease Relevance 0.61 Pain Relevance 0.13
The spatial synthesis, transport, targeting, and mechanistic pathway of FGF-10 and its receptor were studied in a human urothelial cell culture model and in fixed sections of lower urinary tract tissue.
Gene_expression (synthesis) of FGF-10 in urothelial cell
3) Confidence 0.67 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16597614 Disease Relevance 0.19 Pain Relevance 0
Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites, transitional epithelium and smooth muscle cell bundles, both of which were also the exclusive sites of FGF-10 receptor synthesis.
Gene_expression (synthesis) of FGF-10 in transitional epithelium
4) Confidence 0.67 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16597614 Disease Relevance 0.16 Pain Relevance 0
SERPINE2 and FGF10 were highly expressed in PA6-DA cells, with Z-ratios of approximately three and 14 respectively, as compared to both PA6-X and MM55K cells (Table S2).


Gene_expression (expressed) of FGF10 associated with dopamine
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.14
Nonetheless the introduction of FGF10 to chick embryos up-regulated FGF8 expression in the ectoderm through Wnt3a signaling and stimulated SHH expression in the posterior mesoderm followed by outgrowth initiation of chick limb structures [48], [49].
Gene_expression (introduction) of FGF10 in mesoderm
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.15 Pain Relevance 0.35
In addition, PTN, Fibroblast growth factor-10 (FGF10), and serpin peptidase inhibitor, clade E (SERPINE2) also known as glial-derived neurite promoting factor, were classified as heparin binding factors by gene ontology in molecular function at level six.
Gene_expression (classified) of FGF10 in Fibroblast
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.06 Pain Relevance 0.15
In addition, PTN, Fibroblast growth factor-10 (FGF10), and serpin peptidase inhibitor, clade E (SERPINE2) also known as glial-derived neurite promoting factor, were classified as heparin binding factors by gene ontology in molecular function at level six.
Gene_expression (classified) of Fibroblast growth factor-10 in Fibroblast
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.06 Pain Relevance 0.15
Another heparin binding factor, differentially expressed by PA6 cells was FGF-10, which is not considered to have a role in CNS development.
Gene_expression (expressed) of FGF-10
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.15 Pain Relevance 0.34
Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites, transitional epithelium and smooth muscle cell bundles, both of which were also the exclusive sites of FGF-10 receptor synthesis.
Gene_expression (Synthesis) of FGF-10 in smooth muscle cell
10) Confidence 0.26 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16597614 Disease Relevance 0.18 Pain Relevance 0
Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites, transitional epithelium and smooth muscle cell bundles, both of which were also the exclusive sites of FGF-10 receptor synthesis.
Gene_expression (synthesis) of FGF-10 in smooth muscle cell
11) Confidence 0.23 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16597614 Disease Relevance 0.16 Pain Relevance 0
It has been shown that native, intact amniotic membrane (AM) epithelium contains higher levels of epidermal growth factor, keratinocyte growth factor, hepatocyte growth factor, and basic fibroblast growth factor compared with epithelially denuded AM.
Gene_expression (levels) of keratinocyte growth factor in fibroblast
12) Confidence 0.15 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693999 Disease Relevance 0 Pain Relevance 0
Pulp fibroblasts express various pro-inflammatory mediators leading to marked infiltration of inflammatory cells in the progression of pulpitis.
Gene_expression (express) of fibroblasts in fibroblasts associated with inflammatory mediators, inflammation and pulpitis
13) Confidence 0.02 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.42 Pain Relevance 0.29

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