INT128054

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 2.12
Pain Relevance 11.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Per1) protein binding transcription factor activity (Per1) cytoplasm (Per1)
signal transducer activity (Per1)
Anatomy Link Frequency
shell 1
brain 1
amygdala 1
hippocampus 1
nucleus accumbens 1
Per1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 81 99.70 Very High Very High Very High
Ventral tegmentum 11 99.68 Very High Very High Very High
amygdala 24 99.00 Very High Very High Very High
fluoxetine 8 98.68 Very High Very High Very High
Hippocampus 8 98.60 Very High Very High Very High
Nucleus accumbens 24 98.44 Very High Very High Very High
withdrawal 44 97.98 Very High Very High Very High
Glutamate 88 96.32 Very High Very High Very High
agonist 40 96.00 Very High Very High Very High
Serotonin 24 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Weight Loss 8 98.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 8 98.20 Very High Very High Very High
Disease 33 88.96 High High
Endometriosis (extended) 4 84.24 Quite High
Breast Cancer 17 80.96 Quite High
Chronic Disease 4 72.32 Quite High
Hypertension 36 70.32 Quite High
Diabetes Mellitus 8 69.20 Quite High
Depression 12 68.08 Quite High
Sleep Disorders 59 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then, brain and blood samples were collected at each of eight time points (every 3 h: ZT 9; ZT 12; ZT 15; ZT 18; ZT 21; ZT 0; ZT 3; ZT 6) to examine expression of rPER1 and rPER2 and rCLOCK.
Spec (examine) Gene_expression (expression) of rPER1 in brain
1) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.18 Pain Relevance 1.00
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rPER1 in nucleus accumbens associated with nucleus accumbens, hippocampus, amygdala and morphine
2) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.17 Pain Relevance 1.38
In morphine-treated rats, rPER1 and rPER2 expression in the SCN, basolateral amygdala, and nucleus accumbens shell showed robust circadian rhythms that were essentially identical to those in control rats.
Gene_expression (expression) of rPER1 in shell associated with nucleus accumbens, amygdala and morphine
3) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.20 Pain Relevance 1.21
However, robust circadian rhythm in rPER1 expression in the ventral tegmental area was completely phase-reversed in morphine-treated rats.
Gene_expression (expression) of rPER1 in ventral associated with ventral tegmentum and morphine
4) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.18 Pain Relevance 1.33
First, fluoxetine induced behavioral phase-advances associated with down-regulated expression of the clock genes Per1 and Rorbeta and up-regulated expression of Rev-erbalpha during daytime.
Gene_expression (expression) of Per1 associated with fluoxetine
5) Confidence 0.57 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19457131 Disease Relevance 0 Pain Relevance 0.54
Moreover, fluoxetine produced an attenuation of light-induced phase-advances in association with altered expression of Per1, Per2 and Rorbeta during nighttime.
Gene_expression (expression) of Per1 associated with fluoxetine
6) Confidence 0.57 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19457131 Disease Relevance 0 Pain Relevance 0.50
These findings indicate that withdrawal from chronic morphine treatment resulted in desynchronization from the SCN rhythm, with blunting of rPER1 and rPER2 expression in reward-related neurocircuits and PBMCs.
Gene_expression (expression) of rPER1 in SCN associated with withdrawal and morphine
7) Confidence 0.53 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.13 Pain Relevance 1.05
However, few VIP-containing cells rhythmically express per1 and per2 [160,161].
Gene_expression (express) of per1
8) Confidence 0.39 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.10
Nielsen and co-workers [172] showed that VIP induces per1 and per2 gene expression in rat SCN in a phase dependent manner.
Gene_expression (expression) of per1
9) Confidence 0.39 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
Further, Nielsen and co-workers [172] also have shown that VIP induces per1 and per2 expression in a phase-dependent manner, thereby suggesting that VIP is important for the light-induced phase shift at night.


Gene_expression (expression) of per1
10) Confidence 0.39 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.51 Pain Relevance 0.27
Only the lateral group expresses per1 following a light pulse [159].
Gene_expression (expresses) of per1 in lateral
11) Confidence 0.39 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.13
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rPER1 in hippocampus associated with nucleus accumbens, hippocampus, amygdala and morphine
12) Confidence 0.21 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.17 Pain Relevance 1.38
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rPER1 in amygdala associated with nucleus accumbens, hippocampus, amygdala and morphine
13) Confidence 0.21 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.17 Pain Relevance 1.38
Then, brain and blood samples were collected at each of eight time points (every 3 h: ZT 9; ZT 12; ZT 15; ZT 18; ZT 21; ZT 0; ZT 3; ZT 6) to examine expression of rPER1 and rPER2 and rCLOCK.
Spec (examine) Gene_expression (expression) of rPER1 in blood
14) Confidence 0.21 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.18 Pain Relevance 1.00
While one study has noted the presence of per1 and per2 mRNA in the rat MHb (Shieh, 2003), only one published study has investigated clock gene protein expression in the Hb, and did not detect either PER1 or PER2 protein expression in the hamster Hb (Tavakoli-Nezhad and Schwartz, 2006).
Gene_expression (expression) of PER1
15) Confidence 0.20 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0
Moreover, we show that fentanyl induces a strong attenuation of light-induced Syrian hamster Period 1 (shPer1) gene expression during the night.
Gene_expression (expression) of Period 1
16) Confidence 0.07 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.56
In the uterus, estradiol treatment results in bimodal Per1 and Per2 expression whereas control animals had a single peak and estrogen shortens the period of Per2 expression [67, 93].
Gene_expression (expression) of period in uterus
17) Confidence 0.03 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.23 Pain Relevance 0

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