INT128057

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.21
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 95.44 Very High Very High Very High
Opioid 6 86.80 High High
Pain 55 82.84 Quite High
opioid receptor 4 82.04 Quite High
narcan 2 78.08 Quite High
Inflammation 32 73.04 Quite High
Morphine 2 72.40 Quite High
MU agonist 2 71.04 Quite High
Enkephalin 2 66.60 Quite High
Osteoarthritis 44 53.48 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 28 98.24 Very High Very High Very High
Sepsis 23 90.80 High High
Cancer 23 87.80 High High
Apoptosis 4 73.12 Quite High
INFLAMMATION 43 73.04 Quite High
Osteoarthritis 48 53.48 Quite High
Constipation 15 50.00 Quite Low
Encephalopathy 14 47.68 Quite Low
Weight Gain 3 38.48 Quite Low
Pain 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we show that fentanyl induces a strong attenuation of light-induced Syrian hamster Period 1 (shPer1) gene expression during the night.
Positive_regulation (induced) of Gene_expression (expression) of shPer1
1) Confidence 0.59 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.56
Moreover, we show that fentanyl induces a strong attenuation of light-induced Syrian hamster Period 1 (shPer1) gene expression during the night.
Positive_regulation (induces) of Gene_expression (expression) of shPer1
2) Confidence 0.59 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.57
In contrast, we have not observed changes in Per1 levels in breast cancer cells upon CSNK1E suppression, and we failed to detect effects on cell viability after Per1 overexpression (data not shown).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Per1 associated with breast cancer
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.89 Pain Relevance 0
interested in the “absolute” power statistic per se , but interested in
Positive_regulation (interested) of Gene_expression (interested) of per se
4) Confidence 0.10 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0 Pain Relevance 0
An unchanged cerebral net exchange could furthermore involve changes in BBB function per se through a compensatory increase in the unidirectional cerebral efflux of phenylalanine, a parameter that was not assessed in the present study.
Positive_regulation (increase) of Gene_expression (function) of per se
5) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.27 Pain Relevance 0.08
1 induces only 5-LOX mRNA accumulation and not true upregulation of gene expression per se.
Neg (not) Positive_regulation (upregulation) of Gene_expression (expression) of per se
6) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
Clinical efficacy after cross-over (period 1 and 2)
Positive_regulation (over) of Gene_expression (over) of period 1
7) Confidence 0.03 Published 2007 Journal Nutr J Section Body Doc Link PMC1852321 Disease Relevance 0 Pain Relevance 0.14

General Comments

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