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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.82
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
eye 1
PGE2 1
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 98.40 Very High Very High Very High
Acupuncture 110 98.24 Very High Very High Very High
Opioid 34 97.36 Very High Very High Very High
agonist 18 94.98 High High
opioid receptor 9 94.88 High High
Enkephalin 3 83.96 Quite High
Analgesic 24 82.88 Quite High
cINOD 7 81.32 Quite High
Neuropeptide 2 81.32 Quite High
Neurotransmitter 1 80.40 Quite High
Disease Link Frequency Relevance Heat
Rhinitis 50 100.00 Very High Very High Very High
Colorectal Cancer 36 98.64 Very High Very High Very High
INFLAMMATION 8 98.40 Very High Very High Very High
Apoptosis 2 94.40 High High
Sprains And Strains 25 70.68 Quite High
Disease 24 68.00 Quite High
Cancer 17 62.92 Quite High
Death 2 54.40 Quite High
Stress 13 53.24 Quite High
Headache 3 36.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circadian regulation of selected mouse orthologs of human diurnal genes and core circadian-clock genes
Regulation (regulation) of circadian-clock
1) Confidence 0.43 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.12 Pain Relevance 0
-opioid receptor agonist fentanyl induces a phase shift in the circadian rhythm of hamsters independent of any behavioral effects of the opioid.8,9 We showed previously that fentanyl modifies the circadian pacemaker possibly via direct effects on SCN electrical activity and regulation of Per genes.8 This suggests that pathways regulating the circadian clock intersect directly or indirectly with pathways that express opioid receptors.
Regulation (regulation) of Per associated with agonist, opioid receptor and opioid
2) Confidence 0.35 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.84
Our data indicate that opioids can strongly modify the photic responsiveness of the circadian pacemaker and may do so via direct effects on SCN electrical activity and regulation of Per genes.
Regulation (regulation) of Per associated with opioid
3) Confidence 0.20 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.44
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Spec (may) Regulation (affect) of per se in PGE2 associated with inflammation
4) Confidence 0.04 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.27
Thus, disallowance of concomitant medications is needed in a randomised controlled trial for PER in order to detect the specific effects of acupuncture.
Regulation (controlled) of PER associated with rhinitis and acupuncture
5) Confidence 0.03 Published 2009 Journal Trials Section Body Doc Link PMC2715403 Disease Relevance 0.39 Pain Relevance 0.34
We are by no means questioning the value of basic research per se in science in general.
Regulation (value) of per se
6) Confidence 0.03 Published 2010 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2949619 Disease Relevance 0 Pain Relevance 0
Finally, we provided evidence that the catalytic activity per se of all but one pathogenic TPI variant investigated is not affected as a result of the mutation in the TPI gene.
Neg (not) Spec (investigated) Regulation (affected) of per se
7) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.14 Pain Relevance 0
Certainly, eye-position signal per se is not the critical factor modulating the action epoch (HOLD) of this cell.
Neg (not) Regulation (modulating) of per se in eye
8) Confidence 0.00 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2268963 Disease Relevance 0 Pain Relevance 0

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