INT12806

Context Info Confidence 0.67 First Reported 1991 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.19 Pain Relevance 1.35

lipid binding (AP2M1) cytosol (AP2M1) transport (AP2M1) mitochondrion (AP2M1) vesicle-mediated transport (AP2M1) plasma membrane (AP2M1)

Anatomy Link Frequency locus coeruleus 1 AP2M1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 11 99.96 Morphine 2 99.38 Physical dependence 2 99.14 nMDA receptor 1 95.00 Locus ceruleus 1 94.16 agonist 7 92.08 Kappa opioid receptor 4 91.72 Enkephalin 1 84.76 Central nervous system 1 84.52 addiction 6 81.44

Disease Link Frequency Relevance Heat Drug Dependence 2 99.14 Cancer Pain 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

From behavioral, biochemical and molecular biological studies, it is suggested so far that development of physical dependence on morphine results predominantly from an activation of mu 1 and mu 2 opioid receptors which causes functional changes in Gi/o, adenylate cyclase, protein kinases A and C, beta-adrenoceptor and NMDA receptor in the locus coeruleus.

Positive_regulation (activation) of mu 2 in locus coeruleus associated with physical dependence, locus ceruleus, nmda receptor, opioid receptor and morphine

1) Confidence 0.67 Published 1997 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 9160346 Disease Relevance 0.19 Pain Relevance 1.11

Modifications in position 2, 3 and 4 can lead to an increase in mu 1-, mu 2- or delta -site affinity and/or selectivity.

Positive_regulation (increase) of mu 2

2) Confidence 0.49 Published 1991 Journal Pharmazie Section Abstract Doc Link 1654566 Disease Relevance 0 Pain Relevance 0.24

General Comments

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