INT12806

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.19
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (AP2M1) cytosol (AP2M1) transport (AP2M1)
mitochondrion (AP2M1) vesicle-mediated transport (AP2M1) plasma membrane (AP2M1)
Anatomy Link Frequency
locus coeruleus 1
AP2M1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 11 99.96 Very High Very High Very High
Morphine 2 99.38 Very High Very High Very High
Physical dependence 2 99.14 Very High Very High Very High
nMDA receptor 1 95.00 High High
Locus ceruleus 1 94.16 High High
agonist 7 92.08 High High
Kappa opioid receptor 4 91.72 High High
Enkephalin 1 84.76 Quite High
Central nervous system 1 84.52 Quite High
addiction 6 81.44 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 99.14 Very High Very High Very High
Cancer Pain 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From behavioral, biochemical and molecular biological studies, it is suggested so far that development of physical dependence on morphine results predominantly from an activation of mu 1 and mu 2 opioid receptors which causes functional changes in Gi/o, adenylate cyclase, protein kinases A and C, beta-adrenoceptor and NMDA receptor in the locus coeruleus.
Positive_regulation (activation) of mu 2 in locus coeruleus associated with physical dependence, locus ceruleus, nmda receptor, opioid receptor and morphine
1) Confidence 0.67 Published 1997 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 9160346 Disease Relevance 0.19 Pain Relevance 1.11
Modifications in position 2, 3 and 4 can lead to an increase in mu 1-, mu 2- or delta -site affinity and/or selectivity.
Positive_regulation (increase) of mu 2
2) Confidence 0.49 Published 1991 Journal Pharmazie Section Abstract Doc Link 1654566 Disease Relevance 0 Pain Relevance 0.24

General Comments

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