INT128060

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.41
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
PGE2 4
SCN 2
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 99.80 Very High Very High Very High
Inflammation 6 99.08 Very High Very High Very High
Neuropeptide 1 98.78 Very High Very High Very High
Serotonin 4 98.40 Very High Very High Very High
fluoxetine 4 94.96 High High
Enkephalin 1 93.16 High High
MU agonist 1 88.84 High High
Morphine 1 87.24 High High
narcan 1 81.56 Quite High
cINOD 14 81.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.08 Very High Very High Very High
Colorectal Cancer 72 98.64 Very High Very High Very High
Apoptosis 3 94.40 High High
Affective Disorder 1 69.12 Quite High
Cancer 29 54.96 Quite High
Death 2 54.40 Quite High
Sleep Disorders 1 23.44 Low Low
Obesity 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei.
Regulation (affects) of Gene_expression (expression) of Per associated with opioid
1) Confidence 0.52 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.56
Light responses of Per1 and Rorbeta expression at CT0 and those of Per2 and Rev-erbalpha at CT12 were markedly altered by serotonergic activation.
Regulation (altered) of Gene_expression (expression) of Per1
2) Confidence 0.38 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18190911 Disease Relevance 0.07 Pain Relevance 0.49
The phase-shifting effects of exercise on mammalian circadian rhythms are thought to be mediated by inputs to SCN neurons (these include serotonin [24], neuropeptide Y [25], and melatonin [13,26]) and ultimately lead to acute changes in SCN Per1 and Per2 expression [27].
Regulation (changes) of Gene_expression (expression) of Per1 in SCN associated with neuropeptide and serotonin
3) Confidence 0.22 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.10
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Regulation (regulation) of Gene_expression (production) of per se in PGE2 associated with inflammation
4) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.29
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Spec (may) Regulation (affect) of Gene_expression (production) of per se in PGE2 associated with inflammation
5) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.27

General Comments

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