INT128061

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 13.13
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
astrocytes 10
keratinocytes 4
brain 2
neurite 2
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 36 99.00 Very High Very High Very High
Central nervous system 63 98.76 Very High Very High Very High
fibrosis 33 96.96 Very High Very High Very High
agonist 77 95.44 Very High Very High Very High
Spinal cord 7 89.88 High High
Inflammation 92 79.92 Quite High
cva 7 76.24 Quite High
Bile 10 53.00 Quite High
antagonist 12 50.00 Quite Low
Osteoarthritis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Metastasis 12 99.92 Very High Very High Very High
Cancer 58 99.20 Very High Very High Very High
Ureteral Obstruction 16 99.04 Very High Very High Very High
Cv Unclassified Under Development 29 99.00 Very High Very High Very High
Breast Cancer 36 98.96 Very High Very High Very High
Stroke 195 98.92 Very High Very High Very High
Disorder Of Lipid Metabolism 603 98.46 Very High Very High Very High
Middle Cerebral Artery Infarction 119 98.00 Very High Very High Very High
Malignant Neoplastic Disease 2 97.68 Very High Very High Very High
Cicatrix 28 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our in vitro studies which mimic ischemic conditions show increased tPA and PAI-1 expression in OGD astrocytes, and that MSC-astrocyte co-culture concomitantly decreased the PAI-1 expression and increased tPA activity in astrocytes.
Negative_regulation (decreased) of Gene_expression (expression) of PAI in astrocytes
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.93 Pain Relevance 0.08
These data indicate that astrocytes in the IBZ respond to MSC treatment and increase tPA and concomitantly decrease PAI-1 gene expression.


Negative_regulation (decrease) of Gene_expression (expression) of PAI in astrocytes
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.62 Pain Relevance 0
In vitro, MSCs significantly increased tPA levels and concomitantly reduced plasminogen activator inhibitor 1 (PAI-1) expression in astrocytes under normal and oxygen and glucose deprivation (OGD) conditions.
Negative_regulation (reduced) of Gene_expression (expression) of plasminogen activator inhibitor in astrocytes
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815778 Disease Relevance 0.40 Pain Relevance 0.08
Treatment of stroke with MSCs significantly increased tPA expression and decreased PAI-1 expression compared with PBS treatment. tPA activity in the MCAo control brain extract and in the MCAo MSC treated brain extract was measured using zymography.
Negative_regulation (decreased) of Gene_expression (expression) of PAI in brain associated with middle cerebral artery infarction and stroke
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.84 Pain Relevance 0
Deficient PAI-1 expression in mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes.
Negative_regulation (Deficient) of Gene_expression (expression) of PAI-1 in keratinocytes associated with malignant neoplastic disease and cancer
5) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.64 Pain Relevance 0
As a member of the serpine gene family, PAI-1 is the major inhibitor of tPA [21], and is largely produced by reactive astrocytes in the CNS after stroke [65], [66].
Negative_regulation (inhibitor) of Gene_expression (produced) of PAI in astrocytes associated with stroke and central nervous system
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.43 Pain Relevance 0.09
In brain, tissue plasminogen activator (tPA) expression in astrocytes is the primary source of plasminogen activator and PAI-1 is the dominant inhibitor of tPA [21].
Negative_regulation (inhibitor) of Gene_expression (source) of PAI in astrocytes
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.53 Pain Relevance 0.18
Therefore, we hypothesize that MSCs decrease PAI-1 expression and stimulate tPA after ischemia and thereby promote neurite remodeling.
Negative_regulation (decrease) of Gene_expression (expression) of PAI in neurite associated with ischemia
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.66 Pain Relevance 0.22
The findings of decreased expression of PAI-1, TGF-?
Negative_regulation (decreased) of Gene_expression (expression) of PAI-1
9) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.84 Pain Relevance 0.30
Potential reasons for lower circulating PAI-1 concentrations in the elderly include downregulation of PAI-1 expression due to sustained IL-10 expression and age-related changes in tensile strength of tissues and cells, which have been shown to decrease PAI-1 expression [46], [47].
Negative_regulation (decrease) of Gene_expression (expression) of PAI-1
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.67 Pain Relevance 0.09
Potential reasons for lower circulating PAI-1 concentrations in the elderly include downregulation of PAI-1 expression due to sustained IL-10 expression and age-related changes in tensile strength of tissues and cells, which have been shown to decrease PAI-1 expression [46], [47].
Negative_regulation (downregulation) of Gene_expression (expression) of PAI-1
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.70 Pain Relevance 0.10
Deficient PAI-1 expression in mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes.
Negative_regulation (prevented) of Gene_expression (expression) of PAI-1 in keratinocytes associated with malignant neoplastic disease and cancer
12) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.64 Pain Relevance 0
After 2 weeks, the expression of uPA and PAI-1 began to decrease and reached nearly normal level at 12 weeks.
Negative_regulation (decrease) of Gene_expression (expression) of PAI-1
13) Confidence 0.15 Published 2005 Journal Chin. Med. J. Section Body Doc Link 15978208 Disease Relevance 0.06 Pain Relevance 0
Atorvastatin increased Smad3 phosphorylation associated to elevated PAI-1 expression, collagen deposition and SMA staining, indicating that the TGF-?
Negative_regulation (deposition) of Gene_expression (expression) of PAI-1
14) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.56 Pain Relevance 0.03
Several other properties of HDL beyond its involvement in the RCT pathway exert additional anti-atherogenic influence.16,17 HDL has been shown to directly stimulate tissue plasminogen activator (tPA) and inhibit the expression of plasminogen activator inhibitor-1 (PAI-1).
Negative_regulation (inhibit) of Gene_expression (expression) of PAI-1 associated with disorder of lipid metabolism
15) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.24 Pain Relevance 0.05
Several other properties of HDL beyond its involvement in the RCT pathway exert additional anti-atherogenic influence.16,17 HDL has been shown to directly stimulate tissue plasminogen activator (tPA) and inhibit the expression of plasminogen activator inhibitor-1 (PAI-1).
Negative_regulation (inhibit) of Gene_expression (expression) of plasminogen activator inhibitor-1 associated with disorder of lipid metabolism
16) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.24 Pain Relevance 0.05
The uPA activity and levels of uPA, suPAR, and PAI-1 were significantly decreased after SH injections in TMJs of OA patients (P < .05), and there was no difference after saline injection.
Negative_regulation (decreased) of Gene_expression (levels) of PAI-1
17) Confidence 0.05 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.12 Pain Relevance 0

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