INT128069

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Context Info
Confidence 0.81
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 0.65
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cartpt) extracellular region (Cartpt)
Anatomy Link Frequency
Lever 4
nucleus accumbens 2
Cartpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 34 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
tetrodotoxin 96 99.96 Very High Very High Very High
Somatostatin 11 99.08 Very High Very High Very High
Dopamine 39 98.76 Very High Very High Very High
Nucleus accumbens 114 98.08 Very High Very High Very High
Neurotransmitter 11 96.36 Very High Very High Very High
spinal dorsal horn 1 93.56 High High
drug abuse 2 90.72 High High
Disease Link Frequency Relevance Heat
Nociception 7 98.80 Very High Very High Very High
Stress 57 90.92 High High
Drug Dependence 2 90.72 High High
Pain 2 57.56 Quite High
Recurrence 29 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Tremor 12 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens.
Localization (Colocalization) of CART in nucleus accumbens associated with nucleus accumbens, dopamine and enkephalin
1) Confidence 0.81 Published 2006 Journal Neuropeptides Section Title Doc Link 17064765 Disease Relevance 0.09 Pain Relevance 0.70
This strongly suggests that CART peptide can affect glutamatergic neurotransmission as well as the release and effects of SP and SOM in nociception and other sensory processes.
Localization (release) of CART peptide associated with nociception, somatostatin and substance p
2) Confidence 0.73 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17880396 Disease Relevance 0.38 Pain Relevance 0.92
Lever preference during training was assessed using a 2 ‘Lever’ (active, inactive) ×4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) mixed-model ANOVA, whilst reinstatement of responding on both the active and inactive levers was analysed using a 2 ‘Session’ (extinction, reinstatement) ×4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) mixed-model ANOVA.
Localization (0.625) of CART in Lever associated with tetrodotoxin
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.37
Differences in active lever responding at various timepoints across the one hour reinstatement session was assessed using a 4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) X 6 ‘Time’ (10 min, 20 min, 30 min, 40 min, 50 min, 60 min) repeated measures ANOVA.
Localization (2.5) of CART in lever associated with tetrodotoxin
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.30
Lever preference during training was assessed using a 2 ‘Lever’ (active, inactive) ×4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) mixed-model ANOVA, whilst reinstatement of responding on both the active and inactive levers was analysed using a 2 ‘Session’ (extinction, reinstatement) ×4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) mixed-model ANOVA.
Localization (0.625) of CART in Lever associated with tetrodotoxin
5) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.39
Differences in active lever responding at various timepoints across the one hour reinstatement session was assessed using a 4 ‘Treatment’ (Control, TTX, 0.625 µg CART, 2.5 µg CART) X 6 ‘Time’ (10 min, 20 min, 30 min, 40 min, 50 min, 60 min) repeated measures ANOVA.
Localization (0.625) of CART in lever associated with tetrodotoxin
6) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.30
The substance P-CART colocalization exists in a rostro-caudal gradient with more colocalization in rostral regions.
Localization (colocalization) of P-CART associated with substance p
7) Confidence 0.62 Published 2005 Journal Brain Res. Section Abstract Doc Link 15978559 Disease Relevance 0.09 Pain Relevance 0.79
Colocalization of CART with substance P but not enkephalin in the rat nucleus accumbens.
Localization (Colocalization) of CART in nucleus accumbens associated with nucleus accumbens, enkephalin and substance p
8) Confidence 0.62 Published 2005 Journal Brain Res. Section Title Doc Link 15978559 Disease Relevance 0.09 Pain Relevance 0.88
Also leptin increases CART release (196).
Localization (release) of CART
9) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.11

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