INT128078

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.48
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acaa1a) peroxisome (Acaa1a) transferase activity, transferring acyl groups (Acaa1a)
lipid metabolic process (Acaa1a)
Anatomy Link Frequency
PTLs 1
Acaa1a (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 1 99.84 Very High Very High Very High
Dynorphin 2 98.40 Very High Very High Very High
Morphine 6 95.44 Very High Very High Very High
Inflammation 12 83.52 Quite High
Pain 3 83.04 Quite High
Endogenous opioid 1 30.64 Quite Low
Enkephalin 1 25.00 Low Low
agonist 34 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peritonitis 4 91.84 High High
Disorder Of Lipid Metabolism 50 91.20 High High
Body Weight 142 88.88 High High
Obesity 272 87.60 High High
INFLAMMATION 18 83.52 Quite High
Pain 3 83.04 Quite High
Hypertriglyceridemia 2 52.12 Quite High
Overweight 4 50.16 Quite High
Diabetes Mellitus 26 5.00 Very Low Very Low Very Low
Metabolic Disorder 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At time 0 (controls) and 4 and 24h after stimulation, peritoneal leukocytes (PTLs) were counted, PTL levels of opioid peptides (beta-endorphin and dynorphin) measured by radioimmunoassays, while mRNAs coding their respective precursors (POMC and PDYN) and receptors (MOR and KOR) determined by QRT-PCR.
Gene_expression (levels) of PTL in PTLs associated with dynorphin and opioid
1) Confidence 0.58 Published 2005 Journal Immunol. Lett. Section Abstract Doc Link 15979727 Disease Relevance 0.42 Pain Relevance 0.77
-oxidation resulting in 3-ketoacyl-CoA. 3-ketoacyl-CoA is then cleaved by acetyl-CoA acyltransferase 1 (ACAA1) to produce acetyl-CoA [41].
Gene_expression (produce) of ACAA1
2) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0 Pain Relevance 0
-oxidation resulting in 3-ketoacyl-CoA. 3-ketoacyl-CoA is then cleaved by acetyl-CoA acyltransferase 1 (ACAA1) to produce acetyl-CoA [41].
Gene_expression (produce) of acetyl-CoA acyltransferase 1
3) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0 Pain Relevance 0
Coadministration of fenofibrate and E2 significantly decreased ACOX, HD, and thiolase mRNA levels compared with fenofibrate treatment.
Gene_expression (levels) of thiolase mRNA
4) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.51 Pain Relevance 0
Fenofibrate upregulated ACOX, HD, and thiolase mRNA levels whereas E2 downregulated the transcriptional activation of these genes.
Gene_expression (levels) of thiolase mRNA
5) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.55 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox