INT1281

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 203
Total Number 206
Disease Relevance 22.47
Pain Relevance 91.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 23
blood 4
liver 4
striatum 3
locus coeruleus 3
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 542 100.00 Very High Very High Very High
antidepressant 614 99.96 Very High Very High Very High
antagonist 54 99.96 Very High Very High Very High
sSRI 123 99.92 Very High Very High Very High
fluoxetine 339 99.90 Very High Very High Very High
Potency 52 99.90 Very High Very High Very High
agonist 94 99.86 Very High Very High Very High
local anesthetic 22 99.84 Very High Very High Very High
tramadol 12 99.82 Very High Very High Very High
Dopamine 311 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 372 99.88 Very High Very High Very High
Nociception 24 99.84 Very High Very High Very High
Hypotension 28 99.78 Very High Very High Very High
Congenital Anomalies 36 99.64 Very High Very High Very High
Stress 145 99.58 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 7 99.48 Very High Very High Very High
Urological Neuroanatomy 47 99.36 Very High Very High Very High
Heart Rate Under Development 23 99.24 Very High Very High Very High
Pressure And Volume Under Development 75 99.20 Very High Very High Very High
Nicotine Addiction 53 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several lines of evidence suggest that treatment with selegiline at doses that exceed levels required for inhibition of MAO can produce distinct pharmacologic effects.
Negative_regulation (inhibition) of MAO
1) Confidence 0.59 Published 2005 Journal Behav Pharmacol Section Abstract Doc Link 15706133 Disease Relevance 0.07 Pain Relevance 0.63
Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects.
Negative_regulation (inhibitor) of monoamine oxidase associated with monoamine
2) Confidence 0.59 Published 2005 Journal Behav Pharmacol Section Abstract Doc Link 15706133 Disease Relevance 0.06 Pain Relevance 0.50
Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects.
Negative_regulation (inhibitor) of MAO associated with monoamine
3) Confidence 0.59 Published 2005 Journal Behav Pharmacol Section Abstract Doc Link 15706133 Disease Relevance 0.06 Pain Relevance 0.51
This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO).
Negative_regulation (inhibit) of monoamine oxidase associated with monoamine
4) Confidence 0.59 Published 1986 Journal Life Sci. Section Abstract Doc Link 3083168 Disease Relevance 0 Pain Relevance 0.51
This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO).
Negative_regulation (inhibit) of MAO associated with monoamine
5) Confidence 0.59 Published 1986 Journal Life Sci. Section Abstract Doc Link 3083168 Disease Relevance 0 Pain Relevance 0.52
All local anesthetics tested at 1 x 10(-7) M to 1 x 10(-3) M inhibited MAO activity in rat liver mitochondria with 5-hydroxytryptamine (5-HT) as substrate.
Negative_regulation (inhibited) of MAO in liver associated with local anesthetic
6) Confidence 0.59 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6285048 Disease Relevance 0 Pain Relevance 0.66
Inhibition of MAO by local anesthetics other than dibucaine was reversible.
Negative_regulation (Inhibition) of MAO associated with local anesthetic
7) Confidence 0.59 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6285048 Disease Relevance 0 Pain Relevance 0.77
Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects which can prevent decreases in dopamine efflux that follow opiate withdrawal.
Negative_regulation (inhibitor) of monoamine oxidase associated with dopamine, opiate, withdrawal and monoamine
8) Confidence 0.59 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 15519537 Disease Relevance 0.06 Pain Relevance 0.88
Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects which can prevent decreases in dopamine efflux that follow opiate withdrawal.
Negative_regulation (inhibitor) of MAO associated with dopamine, opiate, withdrawal and monoamine
9) Confidence 0.59 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 15519537 Disease Relevance 0.06 Pain Relevance 0.88
Since the four antagonists tested inhibited at least one form of MAO, and yet not all of these MAO inhibitors lowered blood pressure, we suggest that our results are consistent with the view that the hypotensive action of MAO inhibitors is not necessarily related to inhibition of MAO.
Negative_regulation (inhibition) of MAO in blood associated with pressure volume 2 under development, antagonist and hypotension
10) Confidence 0.59 Published 1985 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3839173 Disease Relevance 0.38 Pain Relevance 0.23
We hypothesized that methadone might exert its antidepressant effects through monoamine oxidase (MAO) inhibition.
Negative_regulation (inhibition) of MAO associated with antidepressant, methadone and monoamine
11) Confidence 0.59 Published 1983 Journal Biol. Psychiatry Section Abstract Doc Link 6685534 Disease Relevance 0.17 Pain Relevance 0.97
We hypothesized that methadone might exert its antidepressant effects through monoamine oxidase (MAO) inhibition.
Negative_regulation (inhibition) of monoamine oxidase associated with antidepressant, methadone and monoamine
12) Confidence 0.59 Published 1983 Journal Biol. Psychiatry Section Abstract Doc Link 6685534 Disease Relevance 0.17 Pain Relevance 0.97
This study does not support the hypothesis that methadone acts as an antidepressant through MAO inhibition, at least not following acute administration of this exogenous opioid.
Negative_regulation (inhibition) of MAO associated with antidepressant, methadone and opioid
13) Confidence 0.59 Published 1983 Journal Biol. Psychiatry Section Abstract Doc Link 6685534 Disease Relevance 0.13 Pain Relevance 1.30
These results provide evidence on the in vitro and in vivo inhibition of monoamine oxidase A by fluoxetine.
Negative_regulation (inhibition) of monoamine oxidase associated with fluoxetine and monoamine
14) Confidence 0.59 Published 1999 Journal Synapse Section Abstract Doc Link 10051109 Disease Relevance 0 Pain Relevance 0.59
Monoamine oxidase A (MAO-A) inhibition was investigated both in vitro and in vivo in rat brains by using the radioligand, 18F-fluoroclorgyline (N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropa rgylamine).
Negative_regulation (inhibition) of Monoamine oxidase in brains associated with monoamine
15) Confidence 0.59 Published 1999 Journal Synapse Section Abstract Doc Link 10051109 Disease Relevance 0 Pain Relevance 0.38
Monoamine oxidase A inhibition by fluoxetine: an in vitro and in vivo study.
Negative_regulation (inhibition) of Monoamine oxidase associated with fluoxetine and monoamine
16) Confidence 0.59 Published 1999 Journal Synapse Section Title Doc Link 10051109 Disease Relevance 0 Pain Relevance 0.59
Clorgyline inhibited MAO-A by 95%, with 30% inhibition of MAO-B.
Negative_regulation (inhibition) of MAO-B
17) Confidence 0.59 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8858937 Disease Relevance 0 Pain Relevance 0.45
Chronic treatment with the MAO-B inhibitors reduced striatal MAO-B activity by 90%, with 15% (TVP-1012) or 40% (deprenyl) inhibition of MAO-A.
Negative_regulation (reduced) of MAO-B
18) Confidence 0.59 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8858937 Disease Relevance 0 Pain Relevance 0.44
Likewise, pargyline and nialamide, which inhibit monoamine oxidase, potentiated the release of 5-HT, although they were without effect upon 5-HT uptake.
Negative_regulation (inhibit) of monoamine oxidase associated with monoamine
19) Confidence 0.59 Published 1989 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2482259 Disease Relevance 0 Pain Relevance 0.14
Selegiline is an inhibitor of type B monoamine oxidase (MAO) with psychostimulant effects that can decrease morphine-reinforced and non-reinforced responding.
Negative_regulation (inhibitor) of MAO associated with morphine and monoamine
20) Confidence 0.59 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17157368 Disease Relevance 0 Pain Relevance 0.30

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