INT128143

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
liver 2
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 18 100.00 Very High Very High Very High
agonist 4 89.88 High High
opioid receptor 2 89.32 High High
methadone 3 75.00 Quite High
alcohol 2 75.00 Quite High
Opioid 3 50.00 Quite Low
mu opioid receptor 3 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Heroin induced the synthesis of M6G and decreased the synthesis of M3G.
Negative_regulation (decreased) of Gene_expression (synthesis) of M3G
1) Confidence 0.09 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15986196 Disease Relevance 0 Pain Relevance 0
We have also shown that heroin-treated rats exhibit measurable levels of M6G (which is usually undetectable in this species) and reduced levels of M3G.
Negative_regulation (reduced) of Gene_expression (levels) of M3G
2) Confidence 0.09 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15986196 Disease Relevance 0 Pain Relevance 0.63
We have previously found that repeated exposure to heroin reduces liver synthesis of morphine-3-glucuronide (M3G) and increases the production of morphine-6-glucuronide (M6G), which normally is not formed in the rat.
Negative_regulation (reduces) of Gene_expression (synthesis) of M3G in liver associated with morphine
3) Confidence 0.06 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.20
RESULTS: Heroin inhibited M3G synthesis and induced the formation of M6G, which under basal conditions is not synthesized in rats.
Negative_regulation (inhibited) of Gene_expression (synthesis) of M3G
4) Confidence 0.04 Published 2008 Journal Drug Alcohol Depend Section Body Doc Link 18597954 Disease Relevance 0 Pain Relevance 0

General Comments

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