INT128151

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.00
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Reg3a)
Anatomy Link Frequency
Acinar cell 2
Reg3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 100.00 Very High Very High Very High
Inflammation 13 99.84 Very High Very High Very High
alcohol 2 99.60 Very High Very High Very High
fibrosis 4 92.16 High High
abdominal pain 1 83.28 Quite High
Pain 5 38.16 Quite Low
palliative 1 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 13 100.00 Very High Very High Very High
INFLAMMATION 13 99.84 Very High Very High Very High
Fibrosis 5 92.16 High High
Abdominal Pain 1 83.28 Quite High
Pancreatic Cancer 4 75.00 Quite High
Alcohol Addiction 1 71.52 Quite High
Alcoholic Pancreatitis 2 62.16 Quite High
Nicotine Addiction 2 50.00 Quite Low
Pain 4 38.16 Quite Low
Steatorrhea 1 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acinar cell stress was manifested by a significant up-regulation of pancreatitis-associated protein expression (PAP) in smoke-exposed animals (smoke-exposed 6,932 +/- 1,236 vs control 3,608 +/- 305, p < 0.05).
Positive_regulation (up-regulation) of pancreatitis-associated protein in Acinar cell
1) Confidence 0.24 Published 2006 Journal Am. J. Gastroenterol. Section Body Doc Link 16405548 Disease Relevance 0 Pain Relevance 0
Proteins produced by acinar cells and characteristic for inflammation, e.g., pancreatitis-associated protein, are highly upregulated.
Positive_regulation (upregulated) of pancreatitis-associated protein in acinar cells associated with inflammation and pancreatitis
2) Confidence 0.09 Published 2009 Journal Physiol. Genomics Section Abstract Doc Link 19435834 Disease Relevance 1.42 Pain Relevance 0.76
Chronic pancreatitis is mostly caused by heavy alcohol consumption and is characterized by the onset of symptoms in the fourth and fifth decade.
Positive_regulation (caused) of pancreatitis associated with chronic pancreatitis and alcohol
3) Confidence 0.01 Published 2005 Journal Praxis Section Abstract Doc Link 15986640 Disease Relevance 0.59 Pain Relevance 0.35

General Comments

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