INT128159

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 29
Total Number 39
Disease Relevance 29.50
Pain Relevance 8.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
Anatomy Link Frequency
reticulum 4
arms 2
fibroblasts 1
PC-3 1
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 82 100.00 Very High Very High Very High
cINOD 51 99.96 Very High Very High Very High
agonist 34 85.40 High High
palliative 3 83.16 Quite High
Inflammation 60 79.76 Quite High
ischemia 2 75.76 Quite High
Inflammatory response 24 71.36 Quite High
imagery 4 67.48 Quite High
abdominal pain 1 66.84 Quite High
alcohol 5 54.24 Quite High
Disease Link Frequency Relevance Heat
Stress 220 100.00 Very High Very High Very High
Apoptosis 343 99.90 Very High Very High Very High
Hepatitis C Virus Infection 27 99.64 Very High Very High Very High
Stomach Cancer 5 98.84 Very High Very High Very High
Cancer 307 98.72 Very High Very High Very High
Colon Cancer 13 98.68 Very High Very High Very High
Toxicity 116 98.32 Very High Very High Very High
Death 197 98.28 Very High Very High Very High
Chromosome Aberrations 2 98.04 Very High Very High Very High
Targeted Disruption 17 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The translation of the ATF4 transcription factor is positively regulated by PERK activation in cultured fibroblasts subjected to ER-stress and results in the transcriptional upregulation of GADD153/CHOP.
Positive_regulation (upregulation) of GADD153 in fibroblasts associated with stress
1) Confidence 0.67 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.29 Pain Relevance 0.07
ER stress-induced phosphorylation of alpha-subunit of eukaryotic initiation factor-2 (eIF2alpha) has been reported to be involved in CHOP induction.
Positive_regulation (induction) of CHOP associated with stress
2) Confidence 0.67 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.29 Pain Relevance 0.16
The most remarkable change was the up-regulation of GADD153/CHOP, an endoplasmic reticulum stress-regulated gene.
Positive_regulation (up-regulation) of GADD153/CHOP in reticulum associated with stress
3) Confidence 0.65 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.41 Pain Relevance 0.47
Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study.
Positive_regulation (Induction) of GADD153/CHOP in PC-3 associated with stress and qutenza
4) Confidence 0.65 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 18533110 Disease Relevance 0.40 Pain Relevance 0.58
Activation of GADD153/CHOP protein was corroborated by immunofluorescence and Western blot.
Positive_regulation (Activation) of GADD153/CHOP
5) Confidence 0.65 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.42 Pain Relevance 0.48
The study also demonstrates an OS benefit at 3 years with rituximab maintenance when patients who received R-CHOP and CHOP induction are analyzed together.
Positive_regulation (induction) of CHOP
6) Confidence 0.62 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.79 Pain Relevance 0
Experiments using siRNA and an intracellular Ca(2+) chelator revealed that Ca(2+)-dependent up-regulation of ATF4 and CHOP is involved in this up-regulation of PUMA.
Positive_regulation (up-regulation) of CHOP
7) Confidence 0.60 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17368424 Disease Relevance 0.84 Pain Relevance 0.21
The study also demonstrates an OS benefit at 3 years with rituximab maintenance when patients who received R-CHOP and CHOP induction are analyzed together.
Positive_regulation (induction) of R-CHOP
8) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.80 Pain Relevance 0
Even when rituximab maintenance follows R-CHOP induction the median PFS is more than doubled.
Positive_regulation (induction) of R-CHOP
9) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.80 Pain Relevance 0
However this study provides no evidence of a significant OS benefit attributable to rituximab maintenance in the group who received R-CHOP induction although the study was not designed to detect such a difference.
Positive_regulation (induction) of R-CHOP
10) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.79 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (superiority) of R-CHOP in arms
11) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (superiority) of CHOP in arms
12) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.24 Pain Relevance 0
We show that DMC increases intracellular free calcium levels and potently triggers the ESR in various tumor cell lines, as indicated by transient inhibition of protein synthesis, activation of ER stress-associated proteins GRP78/BiP, CHOP/GADD153, and caspase-4, and subsequent tumor cell death.
Positive_regulation (activation) of CHOP associated with stress, cancer and death
13) Confidence 0.49 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17431104 Disease Relevance 1.28 Pain Relevance 0.16
We show that DMC increases intracellular free calcium levels and potently triggers the ESR in various tumor cell lines, as indicated by transient inhibition of protein synthesis, activation of ER stress-associated proteins GRP78/BiP, CHOP/GADD153, and caspase-4, and subsequent tumor cell death.
Positive_regulation (activation) of GADD153 associated with stress, cancer and death
14) Confidence 0.49 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17431104 Disease Relevance 1.28 Pain Relevance 0.16
The most remarkable change was the up-regulation of GADD153/CHOP, an endoplasmic reticulum stress-regulated gene.
Positive_regulation (up-regulation) of GADD153/CHOP in reticulum associated with stress
15) Confidence 0.47 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.41 Pain Relevance 0.47
Activation of GADD153/CHOP protein was corroborated by immunofluorescence and Western blot.
Positive_regulation (Activation) of GADD153/CHOP
16) Confidence 0.47 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.42 Pain Relevance 0.48
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (activated) of GADD153 associated with stress and qutenza
17) Confidence 0.45 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Chop associated with stress and qutenza
18) Confidence 0.45 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of GADD153 associated with stress and qutenza
19) Confidence 0.45 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (activated) of Chop associated with stress and qutenza
20) Confidence 0.45 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.22 Pain Relevance 0.74

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