INT128160

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
Anatomy Link Frequency
reticulum 2
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 97.36 Very High Very High Very High
qutenza 7 92.24 High High
cytokine 1 91.92 High High
Paracetamol 1 86.48 High High
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Lymphatic System Cancer 3 100.00 Very High Very High Very High
T-cell Lymphoma 4 99.00 Very High Very High Very High
Apoptosis 8 97.72 Very High Very High Very High
INFLAMMATION 2 96.34 Very High Very High Very High
Cancer 1 86.28 High High
Agranulocytosis 5 85.32 High High
Death 3 84.64 Quite High
Autoimmune Hemolytic Anemia 1 81.28 Quite High
Lymphadenopathy 2 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most remarkable change was the up-regulation of GADD153/CHOP, an endoplasmic reticulum stress-regulated gene.
Regulation (regulated) of GADD153/CHOP in reticulum associated with stress
1) Confidence 0.57 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.42 Pain Relevance 0.48
The response of the lymphoma to conventional chemotherapy (CHOP and ESHAP) was poor.
Regulation (response) of CHOP associated with lymphatic system cancer
2) Confidence 0.39 Published 2009 Journal Rinsho Ketsueki Section Abstract Doc Link 19265300 Disease Relevance 1.41 Pain Relevance 0.13
We recently reported that nonsteroidal anti-inflammatory drug (NSAID)-induced gastric lesions involve NSAID-induced apoptosis of gastric mucosal cells, which in turn involves the endoplasmic reticulum stress response, in particular the up-regulation of CCAAT/enhancer-binding protein homologous transcription factor (CHOP).
Regulation (regulation) of CHOP in reticulum associated with stress, inflammation, cinod and apoptosis
3) Confidence 0.03 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15987693 Disease Relevance 0.62 Pain Relevance 0.68

General Comments

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