INT128161

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 17.14
Pain Relevance 5.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
Anatomy Link Frequency
arms 3
PC-3 2
liver 1
MCF-7 1
reticulum 1
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 57 99.56 Very High Very High Very High
Arthritis 26 98.72 Very High Very High Very High
cINOD 25 96.00 Very High Very High Very High
Inflammation 55 87.20 High High
ischemia 2 83.20 Quite High
imagery 5 75.20 Quite High
alcohol 7 71.96 Quite High
COX2 2 68.16 Quite High
agonist 33 50.00 Quite Low
backache 2 43.04 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 133 99.90 Very High Very High Very High
Stress 150 99.70 Very High Very High Very High
Hodgkin's Disease 128 99.64 Very High Very High Very High
Lung Cancer 1 99.44 Very High Very High Very High
Arthritis 25 98.72 Very High Very High Very High
Death 95 98.52 Very High Very High Very High
Hepatitis C Virus Infection 27 97.68 Very High Very High Very High
Breast Cancer 2 97.60 Very High Very High Very High
Toxicity 68 96.76 Very High Very High Very High
Alcoholic Liver Diseases 19 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The JNK inhibitor SP600125 down-regulated the expression of IRE1, Chop, and LC3II induced by DHC, thapsigargin, and MG132 [N-benzoyloxycarbonyl (Z)-Leu-Leu-leucinal].
Gene_expression (expression) of Chop
1) Confidence 0.75 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19139269 Disease Relevance 0.45 Pain Relevance 0.45
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Gene_expression (levels) of GADD153 associated with stress and qutenza
2) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Gene_expression (levels) of Chop associated with stress and qutenza
3) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor.
Gene_expression (expression) of CHOP associated with stress and apoptosis
4) Confidence 0.75 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.26 Pain Relevance 0.17
Blockage of GADD153/CHOP expression by small interfering RNA, significantly reduced capsaicin-induced cell death in PC-3 cells.
Gene_expression (expression) of GADD153/CHOP in PC-3 associated with qutenza and death
5) Confidence 0.72 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.44 Pain Relevance 0.51
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Gene_expression (over) of CHOP in arms
6) Confidence 0.66 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Gene_expression (over) of R-CHOP in arms
7) Confidence 0.66 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Blockage of GADD153/CHOP expression by small interfering RNA, significantly reduced capsaicin-induced cell death in PC-3 cells.
Gene_expression (expression) of GADD153/CHOP in PC-3 associated with qutenza and death
8) Confidence 0.63 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18533110 Disease Relevance 0.44 Pain Relevance 0.51
In fact, purine nucleosides such as fludarabine have replaced single-agent alkylating drugs as the treatment of choice for previously untreated patients and produce significantly higher response rates than such combination therapies as CAP or CHOP (Rai et al 2000; Leporrier et al 2001).
Gene_expression (produce) of CHOP
9) Confidence 0.58 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 1.52 Pain Relevance 0
With a median follow-up of 2 years, EFS and OS were also significantly improved in the R-CHOP arm, with 70% of the R-CHOP-treated patients alive compared with 57% of patients in the CHOP-alone arm (p < 0.001 and p = 0.007, respectively).36
Gene_expression (improved) of R-CHOP in arm
10) Confidence 0.57 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.31 Pain Relevance 0
However, arthritis is unlikely in this patient as autoimmune manifestation, as it developed during R-CHOP and the NHL responded well to this chemotherapy.
Gene_expression (developed) of R-CHOP associated with hodgkin's disease and arthritis
11) Confidence 0.56 Published 2007 Journal Clin Rheumatol Section Body Doc Link PMC2262146 Disease Relevance 1.70 Pain Relevance 0.21
A gain in PFS of approximately 2.5 years was present whether patients received CHOP induction (42.2 vs 11.6 months, P<0.0001) or R-CHOP induction (51.8 vs 23 months P=0.0043), indicating that the antilymphoma effect of rituximab is not exhausted during induction.
Gene_expression (induction) of R-CHOP
12) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0 Pain Relevance 0
A gain in PFS of approximately 2.5 years was present whether patients received CHOP induction (42.2 vs 11.6 months, P<0.0001) or R-CHOP induction (51.8 vs 23 months P=0.0043), indicating that the antilymphoma effect of rituximab is not exhausted during induction.
Gene_expression (induction) of CHOP
13) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0 Pain Relevance 0
Subgroup analysis, as requested by the independent data monitoring committee, demonstrated benefit of maintenance rituximab in the CHOP group but not in the R-CHOP group.
Neg (not) Gene_expression (group) of R-CHOP
14) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.13 Pain Relevance 0
Subgroup analysis, as requested by the independent data monitoring committee, demonstrated benefit of maintenance rituximab in the CHOP group but not in the R-CHOP group.
Gene_expression (group) of CHOP
15) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.14 Pain Relevance 0
It was suggested that the trial be amended with all patients receiving R-CHOP induction followed by randomization to rituximab maintenance or not.
Gene_expression (induction) of R-CHOP
16) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.13 Pain Relevance 0
Immunostaining and confocal microscopic analysis also showed that capsaicin promoted cytoplasmic GADD153 expression and GRP78 nuclear translocation.
Gene_expression (expression) of GADD153 associated with qutenza
17) Confidence 0.48 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19331147 Disease Relevance 0.32 Pain Relevance 0.87
With respect to HCV, several studies have shown that HCV-related proteins, including either core proteins as well as E1 and E2 proteins of the envelope, are able to induce overexpression of C/EBP homologous protein (CHOP) via the UPR response, ER depletion of calcium, and apoptosis in liver cells (HCV replicon cells) [215,216].
Gene_expression (overexpression) of CHOP in liver associated with apoptosis and hepatitis c virus infection
18) Confidence 0.45 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.39 Pain Relevance 0
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Gene_expression (expression) of CHOP in reticulum associated with stress
19) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
In contrast, siRNA for ORP150 stimulated apoptosis and expression of CHOP in the presence of celecoxib but not staurosporine.
Gene_expression (expression) of CHOP associated with apoptosis
20) Confidence 0.38 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17167033 Disease Relevance 0.74 Pain Relevance 0

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