INT128162

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.54
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 80.72 Quite High
Inflammation 1 80.24 Quite High
ischemia 1 76.24 Quite High
Paracetamol 4 5.00 Very Low Very Low Very Low
vincristine 4 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 18 97.96 Very High Very High Very High
Stress 14 97.76 Very High Very High Very High
Parkinson's Disease 2 97.40 Very High Very High Very High
Toxicity 19 92.24 High High
Death 5 86.76 High High
Follicular Lymphoma 78 86.36 High High
Infection 8 83.52 Quite High
INFLAMMATION 4 80.24 Quite High
Lymphatic System Cancer 38 80.08 Quite High
Cv General 4 Under Development 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ER stress-induced phosphorylation of alpha-subunit of eukaryotic initiation factor-2 (eIF2alpha) has been reported to be involved in CHOP induction.
Negative_regulation (involved) of Positive_regulation (induction) of CHOP associated with stress
1) Confidence 0.41 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.30 Pain Relevance 0.16
The study also demonstrates an OS benefit at 3 years with rituximab maintenance when patients who received R-CHOP and CHOP induction are analyzed together.
Negative_regulation (received) of Positive_regulation (induction) of CHOP
2) Confidence 0.38 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.80 Pain Relevance 0
The study also demonstrates an OS benefit at 3 years with rituximab maintenance when patients who received R-CHOP and CHOP induction are analyzed together.
Negative_regulation (received) of Positive_regulation (induction) of R-CHOP
3) Confidence 0.33 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.80 Pain Relevance 0
Selective inhibitors of ERK, p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin-induced cytotoxicity and reduced increased caspase activity.
Negative_regulation (suppressed) of Positive_regulation (induction) of CHOP
4) Confidence 0.24 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.83 Pain Relevance 0.06
Celecoxib-dependent CHOP-induction was partially inhibited by the intracellular Ca2+ chelator but not by the calpain inhibitor.
Negative_regulation (inhibited) of Positive_regulation (induction) of CHOP
5) Confidence 0.05 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15987693 Disease Relevance 0.81 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox