INT128174

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 1.50
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
nucleus 2
CHO 2
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 213 99.98 Very High Very High Very High
Morphine 11 99.50 Very High Very High Very High
cytokine 43 99.44 Very High Very High Very High
Inflammation 178 93.92 High High
addiction 1 90.08 High High
tolerance 4 89.48 High High
mu opioid receptor 4 87.92 High High
bradykinin 12 85.48 High High
antagonist 25 16.08 Low Low
Inflammatory mediators 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 156 99.16 Very High Very High Very High
Pulmonary Disease 204 98.72 Very High Very High Very High
Hypersensitivity 16 98.16 Very High Very High Very High
Disease 87 94.52 High High
INFLAMMATION 212 93.92 High High
Leukemia 10 91.76 High High
Hypertrophy 25 57.20 Quite High
Cancer 18 54.16 Quite High
Aging 21 50.00 Quite Low
Malignant Neoplastic Disease 2 44.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, GPCR-mediated RhoA activation largely occurs through a G12, mainly G?
Positive_regulation (mediated) of Gene_expression (activation) of RhoA
1) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.05
In parallel, to confirm equivalent RhoA protein expression in the cell lysates and uniform protein loading, aliquots of whole cell lysates (typically 10 ?
Positive_regulation (equivalent) of Gene_expression (expression) of RhoA
2) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
Moreover, in keeping with that hypothesis, the finding that agonist-induced G12/RhoA signaling by TP?
Positive_regulation (induced) of Gene_expression (/) of RhoA associated with agonist
3) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
qQ209l,D277N), significantly impaired U46619-mediated RhoA activation and cofilin phosphorylation.
Positive_regulation (mediated) of Gene_expression (activation) of RhoA
4) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0.04
-mediated RhoA signalling, both NO and prostacyclin directly target RhoA phosphorylation at Ser188 through their regulation of PKG and PKA signaling, respectively (data not shown).
Positive_regulation (mediated) of Gene_expression (signalling) of RhoA
5) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Hence, herein, we sought to clarify the involvement of G12 and Gq on TP-mediated RhoA signaling and found that dominant negative forms of G?
Positive_regulation (mediated) of Gene_expression (signaling) of RhoA
6) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0.04
-mediated RhoA signaling in primary human AoSMCs
Positive_regulation (mediated) of Gene_expression (signaling) of RhoA
7) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.06
On the other hand, the inhibitory effect of SIN-1 on U46619-mediated RhoA activation in 1° h.AoSMCs was significantly less in the presence of siRNATP?
Positive_regulation (mediated) of Gene_expression (activation) of RhoA
8) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Chronic morphine treatment significantly enhanced thrombin-stimulated RhoA activity and thrombin-stimulated expression of alpha-actinin, a cytoskeletal anchoring protein, in hMOR-CHO cells.
Positive_regulation (enhanced) of Gene_expression (expression) of RhoA in CHO associated with morphine
9) Confidence 0.23 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15987828 Disease Relevance 0 Pain Relevance 1.08
Both RhoA and CPI-17 expression are increased in rats exposed to repeated allergen challenge [44,45].
Positive_regulation (increased) of Gene_expression (expression) of RhoA
10) Confidence 0.14 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.28 Pain Relevance 0.20
Furthermore, allergic sensitization by itself, without subsequent allergen exposure, appears to be sufficient to induce an increase in RhoA expression [46].
Positive_regulation (induce) of Gene_expression (expression) of RhoA associated with hypersensitivity
11) Confidence 0.14 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.20
The expression of constitutively active RhoG, Cdc42, and RhoA caused the translocation from the cytoplasm to the nucleus of cotransfected STAT3-GFP.
Positive_regulation (caused) of Gene_expression (expression) of RhoA in nucleus
12) Confidence 0.11 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0.05
The involvement of the small G protein RhoA in synergism induced by GPCR agonists and growth factors should also be considered [118], which is interesting given that RhoA expression is increased in animal models of asthma and COPD, as discussed before.
Positive_regulation (increased) of Gene_expression (expression) of RhoA associated with asthma, pulmonary disease and agonist
13) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.26 Pain Relevance 0.35
Furthermore, allergic sensitization by itself, without subsequent allergen exposure, appears to be sufficient to induce an increase in RhoA expression [46].
Positive_regulation (increase) of Gene_expression (expression) of RhoA associated with hypersensitivity
14) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.20

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