INT128176

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.35
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 11 97.44 Very High Very High Very High
Chronic pancreatitis 4 97.12 Very High Very High Very High
mu opioid receptor 4 91.84 High High
Nicotine 58 78.76 Quite High
amygdala 1 77.36 Quite High
midbrain 1 75.68 Quite High
Angina 14 70.44 Quite High
tolerance 4 69.92 Quite High
addiction 39 68.80 Quite High
Inflammation 55 50.00 Quite Low
Disease Link Frequency Relevance Heat
Metastasis 55 99.52 Very High Very High Very High
Cancer 213 98.88 Very High Very High Very High
Adhesions 52 97.28 Very High Very High Very High
Pancreatitis 4 97.12 Very High Very High Very High
Infection 104 96.28 Very High Very High Very High
Herpes Simplex Virus 238 95.88 Very High Very High Very High
Disease 40 93.88 High High
Adenocarcinoma 104 92.52 High High
Pancreatic Cancer 16 79.48 Quite High
Urological Neuroanatomy 1 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
isoforms to regulate RhoA signaling.
Regulation (regulate) of RhoA
1) Confidence 0.44 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.52 Pain Relevance 0.07
-mediated aggregation and secretion and the G12/Rho-mediated shape change while cGMP/PKG signaling inhibits the former Gq/Ca2+ dependent mechanism but does not affect the latter RhoA/Ca2+ independent mechanism [35].
Neg (not) Regulation (affect) of RhoA
2) Confidence 0.44 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Moreover, in view of the critical involvement of inhibitory agents including prostacyclin and NO, that largely signal through cAMP and cGMP second messengers, in regulating RhoA-dependent mechanisms [1,6,35,36] coupled to their role in differentially regulating TP?
Regulation (regulating) of RhoA
3) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.47 Pain Relevance 0.06
regulate G12/Rho activation and whether that signaling might be differentially regulated by prostacyclin and/or NO.
Spec (whether) Regulation (regulate) of G12/Rho
4) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
to regulate events downstream of RhoA: effector coupling by monitoring U46619-induced F-actin polymerization and cofilin phosphorylation.
Regulation (regulate) of RhoA
5) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
In the present study, we hypothesized that chronic morphine alters the expression and functional effects of G alpha12, a G protein that regulates downstream cytoskeletal proteins via its control of RhoA.
Regulation (control) of RhoA associated with morphine
6) Confidence 0.28 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15987828 Disease Relevance 0 Pain Relevance 0.77
As shown in Figure 3B, RhoA activity was not significantly altered by expression of dnRhoC.
Neg (not) Regulation (altered) of RhoA
7) Confidence 0.20 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.18 Pain Relevance 0
independently regulated RhoA activation and signaling in clonal cells over-expressing TP?
Regulation (regulated) of RhoA
8) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
in a concentration-dependent manner but had no effect on RhoA activation by TP?
Neg (no) Regulation (effect) of RhoA
9) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Next, to understand the role of PGE2 in the regulation of RhoA-GTPase activity of infected cells, we tested the lysates from cells plated on untreated plates for 30?
Regulation (regulation) of RhoA
10) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.61 Pain Relevance 0
Ligand interactions with CDH13 activate signaling pathways including those that alter intracellular Ca2+ and tyrosine kinase, Erk 1/2 kinase, RhoA/ROCK and Rac pathways and NFkB [37-40].
Regulation (alter) of RhoA
11) Confidence 0.12 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853105 Disease Relevance 0.33 Pain Relevance 0.17
Further experiments will also be needed to determine if PDCD10 functions in concert with OSM and Krit1 in signaling the regulation of RhoA and PI3K.


Regulation (regulation) of RhoA
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
RhoA and -C are posttranslationally modified by geranylgeranylation, whereas RhoB can be farnesylated and geranylgeranylated [329,330].
Regulation (modified) of RhoA
13) Confidence 0.10 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.70 Pain Relevance 0
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Regulation (altered) of RhoA associated with metastasis
14) Confidence 0.04 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.50 Pain Relevance 0.19

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