INT12818

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2008
Negated 3
Speculated 3
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 3.23
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
muscle 1
brain 1
peripheral nerve 1
eosinophil 1
IgG-2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 8 100.00 Very High Very High Very High
Peripheral nerve injury 4 100.00 Very High Very High Very High
qutenza 9 99.84 Very High Very High Very High
Neuropathic pain 2 99.84 Very High Very High Very High
intrathecal 2 99.52 Very High Very High Very High
Pain 3 99.30 Very High Very High Very High
neuralgia 1 99.30 Very High Very High Very High
opioid receptor 2 99.24 Very High Very High Very High
Morphine 33 99.18 Very High Very High Very High
Neuropeptide 4 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 10 100.00 Very High Very High Very High
Nervous System Injury 5 100.00 Very High Very High Very High
Infection 87 97.96 Very High Very High Very High
Spinal Cord Injury 140 95.28 Very High Very High Very High
Sclerosis 2 95.20 Very High Very High Very High
Injury 115 91.76 High High
Cancer 67 88.80 High High
Pain 2 87.20 High High
Anaphylaxis 1 82.28 Quite High
Helminth Infection 22 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied whether morphine, a metabolite of heroin, could directly affect the uptake of immunoglobulin G (IgG) complexes by cultured mesangial cells (MC) and macrophages (MP).
Regulation (affect) of IgG in mesangial cells associated with morphine
1) Confidence 0.37 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8498540 Disease Relevance 0.10 Pain Relevance 0.56
MP pretreated with morphine (10(-6) M) also showed significantly (P < 0.02) lower uptake of IgG complexes (control 94,959 +/- 4,980 vs. morphine, 58,360 +/- 11,608 cpm/mg protein).
Regulation (control) of IgG associated with morphine
2) Confidence 0.37 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8498540 Disease Relevance 0.07 Pain Relevance 1.00
Among the monoclonal antibodies produced, IgG2c was not cytotoxic but was able to inhibit the in vitro effects of IgG2a, by blocking eosinophil degranulation and cell-mediated cytotoxicity [53, 54].
Regulation (effects) of IgG2a in eosinophil
3) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.69 Pain Relevance 0
A rat IgG2a isotype control was purchased from Caltag.


Regulation (control) of IgG2a
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0.17 Pain Relevance 0
Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain.
Spec (possible) Regulation (modulation) of IgG in peripheral nerve associated with nervous system injury, allodynia, neuropathic pain, peripheral nerve injury and intrathecal
5) Confidence 0.22 Published 2000 Journal Brain Res. Section Title Doc Link 11011025 Disease Relevance 0.99 Pain Relevance 1.27
The levels of IgA, IgE and IgG in bronchial lavage were also affected by capsaicin treatment; however, the results were heterogeneous.
Regulation (affected) of IgG associated with qutenza
6) Confidence 0.08 Published 1991 Journal Allergy Section Abstract Doc Link 1654749 Disease Relevance 0 Pain Relevance 0.84
The serum anti-KLH IgG antibody titer decreased in the males of the IND 1.0 mg/kg dosing group, the serum levels of anti-KLH IgM, total IgM, and IgG were not changed at all.
Neg (not) Regulation (changed) of IgG
7) Confidence 0.07 Published 2007 Journal Toxicology Section Abstract Doc Link 17320264 Disease Relevance 0.05 Pain Relevance 0.21
Prolonged treatment with morphine, however, resulted in a decrease in host resistance to T. spiralis infection, as indicated by a 1.5-fold increase in numbers of muscle larvae counted in the carcass, but did not affect the T. spiralis-specific IgM, IgG and IgE antibody responses.
Neg (not) Regulation (affect) of IgG in muscle associated with infection and morphine
8) Confidence 0.05 Published 1998 Journal Toxicology Section Abstract Doc Link 9772098 Disease Relevance 0.16 Pain Relevance 0.98
To explore this idea further, we determined the effect of i.c.v. administration of anti-ET-1 IgG (rabbit) on brain opioid receptor and ET receptor expression.
Spec (determined) Regulation (effect) of IgG in brain associated with opioid receptor
9) Confidence 0.01 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541896 Disease Relevance 0 Pain Relevance 0.82
No effects of SEB or dietary supplementation on mucosal IgA and serum IgA and IgG were observed.
Neg (No) Regulation (effects) of IgG
10) Confidence 0.01 Published 2004 Journal J. Nutr. Section Abstract Doc Link 15465764 Disease Relevance 0.07 Pain Relevance 0.08
Cells dissociated from spinal cord tissue (T8-T10) of uninjured controls (Figure 8A) or spinal cord injured rats (Figure 8B &8C) were labeled with a FITC-conjugated anti-PMN antibody and a Cy5-conjugated antibody for C1q, C3, C7 or C5b-9/MAC, or appropriate IgG controls before analyzed on a flow cytometer.
Spec (analyzed) Regulation (controls) of IgG in spinal cord associated with spinal cord
11) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.73 Pain Relevance 0.29
Cultured PMNs double-labeled with both a FITC-conjugated anti-PMN antibody and a Cy5-conjugated antibody for C1q, C3, or C5b-9/MAC, or appropriate IgG controls showed that nearly all cells were PMNs (as shown in Figure 1), and that 30.1% and 24.1% of cultured PMNs were associated with C1q (Figure 5B &5E) and C3 (Figure 5C &5E) respectively.
Regulation (controls) of IgG
12) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.20 Pain Relevance 0.03

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