INT128184

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.30
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
brain 2
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 4 99.16 Very High Very High Very High
imagery 2 99.14 Very High Very High Very High
tolerance 14 98.56 Very High Very High Very High
antinociception 9 96.84 Very High Very High Very High
Root ganglion neuron 1 96.48 Very High Very High Very High
Kinase C 8 94.76 High High
nociceptor 3 94.24 High High
Antinociceptive 2 93.96 High High
qutenza 2 92.92 High High
Hyperalgesia 2 88.88 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 4 99.16 Very High Very High Very High
Cancer 2 96.92 Very High Very High Very High
Alcohol Addiction 2 96.44 Very High Very High Very High
Ganglion Cysts 1 96.16 Very High Very High Very High
Diabetes Mellitus 2 95.96 Very High Very High Very High
Neuropathic Pain 2 95.56 Very High Very High Very High
Hyperalgesia 2 88.88 High High
Nociception 2 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, using both Ca2+-imaging and patch-clamp methods, we show that PMA-induced activation of PKCepsilon is essential for increased sensitivity of desensitized TRPV1.
Positive_regulation (induced) of Positive_regulation (activation) of PKCepsilon associated with imagery
1) Confidence 0.41 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.18 Pain Relevance 0.28
Signaling pathways leading to activation of PKCepsilon remain unknown.
Positive_regulation (leading) of Positive_regulation (activation) of PKCepsilon
2) Confidence 0.13 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.56 Pain Relevance 0.27
Epac, in turn, was upstream of phospholipase C (PLC) and PLD, both of which were necessary for translocation and activation of PKCepsilon.
Positive_regulation (necessary) of Positive_regulation (activation) of PKCepsilon
3) Confidence 0.13 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.55 Pain Relevance 0.37
The prolonged exposure to 70% N2O caused an activation of PKCgamma isoform in the brain, but not the PKCepsilon isoform.
Positive_regulation (caused) of Positive_regulation (activation) of PKCepsilon isoform in brain
4) Confidence 0.13 Published 2007 Journal Neuroscience Section Abstract Doc Link 17681696 Disease Relevance 0 Pain Relevance 1.70

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox