INT128185

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.39
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 100.00 Very High Very High Very High
Morphine 9 98.84 Very High Very High Very High
nociceptor 3 98.56 Very High Very High Very High
nMDA receptor 6 98.40 Very High Very High Very High
qutenza 3 89.28 High High
Serotonin 1 86.64 High High
bradykinin 1 86.20 High High
antagonist 3 82.64 Quite High
IPN 3 75.00 Quite High
Pain 6 73.84 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 100.00 Very High Very High Very High
Injury 1 86.08 High High
Nociception 3 80.08 Quite High
Inflammatory Pain 3 75.00 Quite High
Cancer 1 71.24 Quite High
Alcohol Addiction 1 70.76 Quite High
Diabetes Mellitus 1 70.28 Quite High
Neuropathic Pain 1 69.88 Quite High
Ganglion Cysts 1 69.40 Quite High
Pain 1 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells transfected with tagged PKCepsilon, hydrogen peroxide induced translocation and a reduction in free sulfhydryls of full-length PKCepsilon but not of the deletion mutant lacking the C1A domain.
Gene_expression (transfected) of PKCepsilon
1) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18799680 Disease Relevance 0.50 Pain Relevance 0.70
At designated periods, slices were preserved for immunoblot analysis to observe effects of morphine pretreatment on membrane translocation and total protein expression of nPKCepsilon and phosphorylation of NR1 subunits of NMDA receptors.
Gene_expression (expression) of nPKCepsilon associated with nmda receptor and morphine
2) Confidence 0.65 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.15 Pain Relevance 0.95
We also show that the expression level of PKCepsilon paralleled the amount of phosphorylated TRPV1 protein using an antibody specific for phosphorylated TRPV1 at S800.
Gene_expression (expression) of PKCepsilon
3) Confidence 0.45 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.20
Also, in a behavioral model, cAMP produced mechanical hyperalgesia (tenderness) through Epac, PLC/PLD, and PKCepsilon.
Gene_expression (produced) of PKCepsilon associated with hyperalgesia
4) Confidence 0.21 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.53 Pain Relevance 0.38

General Comments

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