INT12820

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Context Info
Confidence 0.35
First Reported 1990
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 23
Disease Relevance 14.85
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
central nervous system 3
puncture 2
LOC683257 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 462 100.00 Very High Very High Very High
Central nervous system 42 99.68 Very High Very High Very High
Neuropeptide 3 99.04 Very High Very High Very High
Inflammation 47 98.96 Very High Very High Very High
qutenza 9 97.96 Very High Very High Very High
Migraine 21 97.56 Very High Very High Very High
Calcitonin gene-related peptide 1 94.00 High High
headache 21 87.48 High High
Serotonin 1 82.48 Quite High
anesthesia 1 41.76 Quite Low
Disease Link Frequency Relevance Heat
Lumbar Puncture Related Headaches 84 99.96 Very High Very High Very High
Meningoencephalitis 252 99.40 Very High Very High Very High
Neurocysticercosis 21 99.32 Very High Very High Very High
Rhinitis 231 99.28 Very High Very High Very High
INFLAMMATION 46 98.96 Very High Very High Very High
Fever 63 98.36 Very High Very High Very High
Vomiting 63 97.96 Very High Very High Very High
Headache 42 97.56 Very High Very High Very High
Disease 147 97.40 Very High Very High Very High
Eosinophilia 63 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study using the first diagnostic lumbar puncture, IgE intrathecal synthesis was demonstrated but not IgM, IgA or IgG synthesis.
Gene_expression (synthesis) of IgE in puncture associated with lumbar puncture related headaches and intrathecal
1) Confidence 0.35 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.68 Pain Relevance 0.23
Nevertheless, intrathecal synthesis of IgE was demonstrated in both groups of patients.
Gene_expression (synthesis) of IgE associated with intrathecal
2) Confidence 0.35 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.63 Pain Relevance 0.22
In Cuba, there is evidence that no other parasites cause eosinophilic meningoencephalitis, which makes the intrathecal synthesis of IgE a diagnostic tool for research in our environment [21,22].
Gene_expression (synthesis) of IgE associated with rhinitis, meningoencephalitis and intrathecal
3) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.79 Pain Relevance 0.27
The advantage of using the Reibergram for demonstrating IgE intrathecal synthesis is that it shows the fraction of IgE produced in the central nervous system, indicating the local response to the Angiostrongylus cantonensis third stage larvae.
Gene_expression (produced) of IgE in central nervous system associated with central nervous system and intrathecal
4) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.46 Pain Relevance 0.21
No intrathecal IgE synthesis was seen in control patients.


Gene_expression (synthesis) of IgE associated with intrathecal
5) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2607252 Disease Relevance 0.94 Pain Relevance 0.31
In the present study, we investigated intrathecal IgE synthesis in a larger group of children using CSF/serum quotient diagrams (Reibergrams) and report here an extremely high intrathecal immune response.
Spec (investigated) Gene_expression (synthesis) of IgE associated with intrathecal
6) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.97 Pain Relevance 0.22
Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

Background

Gene_expression (synthesis) of IgE associated with rhinitis, meningoencephalitis and intrathecal
7) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Title Doc Link PMC2607252 Disease Relevance 0.99 Pain Relevance 0.25
The levels of IgE in serum and CSF were quantified by N Latex IgE Mono assay in a BN Prospec nephelometer (Dade Behring, Marburg, Germany).
Gene_expression (levels) of IgE
8) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.35 Pain Relevance 0.07
Although IgE intrathecal synthesis is not specific for Angiostrongylus cantonensis, IgE synthesis should always be present in eosinophilic meningoencephalitis caused by the larvae of this parasite.
Gene_expression (synthesis) of IgE associated with rhinitis, meningoencephalitis and intrathecal
9) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.45 Pain Relevance 0.14
The procedure was standardized for the quantification of IgE in both fluids and enabled the detection of intrathecal synthesis of IgE.
Gene_expression (synthesis) of IgE associated with intrathecal
10) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.25 Pain Relevance 0.08
IgE synthesis has an essential role in inflammatory processes of the eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis and should be considered as a diagnostic tool.
Gene_expression (synthesis) of IgE associated with rhinitis, inflammation and meningoencephalitis
11) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.91 Pain Relevance 0.24
Although IgE intrathecal synthesis is not specific for Angiostrongylus cantonensis, IgE synthesis should always be present in eosinophilic meningoencephalitis caused by the larvae of this parasite.
Gene_expression (synthesis) of IgE associated with rhinitis, meningoencephalitis and intrathecal
12) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.45 Pain Relevance 0.14
The quotient diagram, or Reibergram, showed that intrathecal synthesis of IgE was observed for all 13 patients (Fig. 1).
Gene_expression (synthesis) of IgE associated with intrathecal
13) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.44 Pain Relevance 0.16
IgE intrathecal synthesis analyzed by the corresponding quotient diagram (Reibergram) was observed in all patients.
Spec (analyzed) Gene_expression (synthesis) of IgE associated with intrathecal
14) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2607252 Disease Relevance 0.99 Pain Relevance 0.31
All results above the 10th percentile (not shown) demonstrate local IgE production.
Gene_expression (production) of IgE
15) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.44 Pain Relevance 0.14
The advantage of using the Reibergram for demonstrating IgE intrathecal synthesis is that it shows the fraction of IgE produced in the central nervous system, indicating the local response to the Angiostrongylus cantonensis third stage larvae.
Gene_expression (synthesis) of IgE in central nervous system associated with central nervous system and intrathecal
16) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.46 Pain Relevance 0.21
This is supported by the large amount of intrathecally synthesized IgE observed in this study.
Gene_expression (synthesized) of IgE
17) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.44 Pain Relevance 0.15
In an earlier study [9] on four patients diagnosed with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis, it was shown that a local IgE synthesis was detected in the first diagnostic lumbar puncture without intrathecal synthesis of immunoglobulin A (IgA), immunoglobulin M (IgM) or immunoglobulin G (IgG).
Gene_expression (synthesis) of IgE in puncture associated with rhinitis, meningoencephalitis, lumbar puncture related headaches and intrathecal
18) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 1.11 Pain Relevance 0.19
The novelty of these results is that IgE intrathecal synthesis may be considered in our environment as a diagnostic tool, and as an auxiliary diagnostic method in countries, having other parasites that are involved with the central nervous system.


Gene_expression (synthesis) of IgE in central nervous system associated with central nervous system and intrathecal
19) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 1.02 Pain Relevance 0.24
In other countries where it is common to find other parasites in the CSF as for example in neurocysticercosis, the diagnostic value of finding IgE intrathecal synthesis is more limited and would only be an indicator of an eosinophilic meningoencephalitis of parasitic origin.


Gene_expression (synthesis) of IgE associated with rhinitis, meningoencephalitis, neurocysticercosis and intrathecal
20) Confidence 0.27 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.80 Pain Relevance 0.22

General Comments

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