INT128201

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.64
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NCAM1) cell adhesion (NCAM1) plasma membrane (NCAM1)
Anatomy Link Frequency
NK cell 2
T cell 2
blood 1
hepatocyte 1
thyroid 1
NCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 1 99.12 Very High Very High Very High
endometriosis 52 93.12 High High
Dysuria 1 83.56 Quite High
ischemia 1 75.16 Quite High
abdominal pain 2 71.08 Quite High
anesthesia 1 68.16 Quite High
cytokine 15 66.96 Quite High
agonist 1 65.68 Quite High
Hippocampus 7 60.52 Quite High
trigeminal ganglion 15 60.48 Quite High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 235 100.00 Very High Very High Very High
Infection 139 100.00 Very High Very High Very High
Cicatrix 47 99.24 Very High Very High Very High
Opiate Addiction 158 99.04 Very High Very High Very High
Endometriosis 90 99.00 Very High Very High Very High
Metastasis 26 97.88 Very High Very High Very High
Colon Cancer 21 96.20 Very High Very High Very High
Small Cell Lung Cancer 6 96.20 Very High Very High Very High
Neuroendocrine Cancer 13 95.92 Very High Very High Very High
Cancer 144 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adult, evidence for the persistence of PSA-NCAM is restricted to the cerebral cortex [29-31] and peripheral nerve [32], where altered expression of the molecule has also been described in a number of neuropathological conditions [32-38].
Negative_regulation (persistence) of PSA-NCAM in peripheral nerve associated with cerebral cortex
1) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.42 Pain Relevance 0.20
The negative impact of HCV infection on CD56+ T cell function was also observed in the experiments showing that there is a negative association between HCV viral loads and the levels of IFN-?
Negative_regulation (impact) of CD56 in T cell associated with hepatitis c virus infection and infection
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.46 Pain Relevance 0
Pooled CD56+ T SN from each of the study groups was added to the hepatocyte cultures at day 3 postinfection and maintained in the cultures for 48h.
Negative_regulation (Pooled) of CD56 in hepatocyte
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.66 Pain Relevance 0
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Negative_regulation (positive) of CD56 in thyroid
4) Confidence 0.32 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
A decrease of the number of CD56-positive cells in scar and ovarian endometrioses seems to remain in agreement with described NK cell dysfunction, which is considered to contribute to the pathogenesis of endometriosis [22].
Negative_regulation (decrease) of CD56 in NK cell associated with endometriosis and cicatrix
5) Confidence 0.26 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.17 Pain Relevance 0.19
The presence of CD3+ and CD45+ cells was used as an indicator of T cell infiltration and the prevalence of CD4+, CD8+, CD56+ cells as indicators of T helper, T cytotoxic and NK cells, respectively and CD1a was used as a marker for antigen presenting cells (APC).
Negative_regulation (prevalence) of CD56 in T cell
6) Confidence 0.23 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.94 Pain Relevance 0
The number of CD56 positive and CD3
Negative_regulation (number) of CD56
7) Confidence 0.18 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246050 Disease Relevance 0.13 Pain Relevance 0.03
Both CD56bright and CD56dim subsets of NK cells were equally reduced.
Negative_regulation (reduced) of CD56dim in NK cells
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2872666 Disease Relevance 0.08 Pain Relevance 0
Immunohistochemistry revealed that this lesion was positive for synaptophysin and CD56, but negative for chromogranin as well as CD10, CD7, and CD20, consistent with a well-differentiated neuroendocrine tumor.
Negative_regulation (positive) of CD56 associated with neuroendocrine cancer
9) Confidence 0.05 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2386474 Disease Relevance 1.16 Pain Relevance 0.07
Consistent with SAC-induced IFNgamma expression in CD56 NK and NK-T cells, CD56 depletion ablated IFNgamma production in normal whole blood.
Negative_regulation (depletion) of CD56 in blood
10) Confidence 0.03 Published 2005 Journal Shock Section Abstract Doc Link 15988317 Disease Relevance 0 Pain Relevance 0.16

General Comments

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