INT128210

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.88
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 4
kidney 3
heart 1
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.68 Very High Very High Very High
ketamine 2 90.04 High High
anesthesia 5 81.88 Quite High
Potency 3 69.68 Quite High
cINOD 10 52.52 Quite High
antagonist 2 52.04 Quite High
Catecholamine 3 9.96 Low Low
Inflammation 3 5.88 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 84 98.56 Very High Very High Very High
Cardiovascular Disease 9 97.68 Very High Very High Very High
Stress 37 93.16 High High
Body Weight 27 88.72 High High
Pressure And Volume Under Development 2 82.48 Quite High
Nephrotoxicity 6 76.84 Quite High
Hypertension 6 75.00 Quite High
Ulcers 27 70.48 Quite High
Coronary Heart Disease 2 56.56 Quite High
Peptic Ulcer 8 44.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APAP administration caused elevated levels of renal MDA, and marked depletion of GSH levels and antioxidant enzyme activity, and deteriorated the renal functions as assessed by the increased plasma urea and creatinine levels as compared to control rats.
Positive_regulation (caused) of Positive_regulation (levels) of MDA in plasma associated with paracetamol
1) Confidence 0.08 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 19345714 Disease Relevance 0.22 Pain Relevance 0.89
APAP administration caused elevated levels of renal MDA, and marked depletion of GSH levels and antioxidant enzyme activity, and deteriorated the renal functions as assessed by the increased plasma urea and creatinine levels as compared to control rats.
Positive_regulation (elevated) of Positive_regulation (levels) of MDA in plasma associated with paracetamol
2) Confidence 0.08 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 19345714 Disease Relevance 0.22 Pain Relevance 0.89
This was apparent from the stimulated lipid and protein oxidation leading to increased accumulation of MDA and protein carbonyls, as well as reduction in the tissue DNA contents.
Positive_regulation (increased) of Positive_regulation (accumulation) of MDA
3) Confidence 0.07 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2170955 Disease Relevance 0.35 Pain Relevance 0.09
For those points of view, some coffee contents can help increase antioxidant defense system, but the other contents or the decomposed contents of coffee which can come with roasting degree, type of coffee bean, the amount of consumption and preparation method can be pro oxidant [14,21], those can induce increased MDA levels.
Positive_regulation (induce) of Positive_regulation (increased) of MDA
4) Confidence 0.06 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.51 Pain Relevance 0
L-NAME caused GSH depletion in the heart and kidney tissues with a concomitant increase in MDA contents in both the tissues.
Positive_regulation (caused) of Positive_regulation (increase) of MDA in kidney
5) Confidence 0.05 Published 2004 Journal Recept. Channels Section Abstract Doc Link 15989079 Disease Relevance 0.63 Pain Relevance 0.11
For those points of view, some coffee contents can help increase antioxidant defense system, but the other contents or the decomposed contents of coffee which can come with roasting degree, type of coffee bean, the amount of consumption and preparation method can be pro oxidant [14,21], those can induce increased MDA levels.
Positive_regulation (increased) of Positive_regulation (induce) of MDA
6) Confidence 0.04 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.51 Pain Relevance 0
By all accounts, this study observed coffee intake induced significant increase in MDA levels and significant decrease in HDL-cholesterol, and other studies reported that coffee intake increased tHcy.
Positive_regulation (induced) of Positive_regulation (increase) of MDA associated with disorder of lipid metabolism
7) Confidence 0.04 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.81 Pain Relevance 0
L-NAME caused GSH depletion in the heart and kidney tissues with a concomitant increase in MDA contents in both the tissues.
Positive_regulation (caused) of in heart Positive_regulation (increase) of MDA in kidney
8) Confidence 0.02 Published 2004 Journal Recept. Channels Section Abstract Doc Link 15989079 Disease Relevance 0.63 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox