INT12823

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Context Info
Confidence 0.64
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.23
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SH-SY5Y 1
RVM 1
lung 1
C cells 1
afferent neurons 1
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 10 100.00 Very High Very High Very High
narcan 24 99.82 Very High Very High Very High
Inflammation 4 99.78 Very High Very High Very High
Morphine 25 99.08 Very High Very High Very High
antagonist 24 98.86 Very High Very High Very High
mu opioid receptor 25 96.84 Very High Very High Very High
Pain 6 95.16 Very High Very High Very High
Glutamate 4 95.00 High High
Rostral ventromedial medulla 8 93.92 High High
MU agonist 6 93.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.78 Very High Very High Very High
Lung Cancer 4 99.64 Very High Very High Very High
Apoptosis 136 99.32 Very High Very High Very High
Urological Neuroanatomy 8 98.80 Very High Very High Very High
Suicidal Behaviour 4 98.48 Very High Very High Very High
Neuroblastoma 3 98.06 Very High Very High Very High
Infection 26 96.76 Very High Very High Very High
Pain 4 95.16 Very High Very High Very High
Aging 1 94.12 High High
Injury 1 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative autoradiography with [3H]DAGO revealed region specific increases in mu receptor density with age.
Positive_regulation (increases) of mu receptor
1) Confidence 0.64 Published 1990 Journal Brain Res. Section Abstract Doc Link 2176118 Disease Relevance 0.36 Pain Relevance 0.09
Upregulation of TNFAIP3, TNFAIP8, TNFRSF12A, FAIM3, and CFLAR are important to inhibit caspase-8 activation, and may be direct targets of Shigella T3SS effector proteins or result from NF-?
Positive_regulation (Upregulation) of FAIM3
2) Confidence 0.29 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.05 Pain Relevance 0
The human neuroblastoma cell line SH-SY5Y was used to demonstrate morphine-induced down-regulation and naloxone-induced up-regulation of opiate receptors in a mu receptor containing neuronally derived preparation capable of desensitization to morphine.
Positive_regulation (up-regulation) of mu receptor in SH-SY5Y associated with neuroblastoma, narcan, opiate and morphine
3) Confidence 0.13 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8097244 Disease Relevance 0.17 Pain Relevance 0.78
Peripheral inflammation causes an increase in mu receptor levels on peripheral terminals of primary afferent neurons.
Positive_regulation (increase) of mu receptor in afferent neurons associated with inflammation
4) Confidence 0.07 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054115 Disease Relevance 0.10 Pain Relevance 0.33
Prolonged (24 h) activation of the mu receptor desensitized both mu and ORL1 receptor-mediated inhibition of forskolin-stimulated cAMP accumulation and upregulated GRK2 levels in SH-SY5Y and BE(2)-C cells.
Positive_regulation (activation) of mu receptor in C cells
5) Confidence 0.06 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.10 Pain Relevance 0.26
Nitric oxide (NO) release is mediated through the mu3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung.
Positive_regulation (mediated) of mu3 receptor in lung associated with lung cancer and morphine
6) Confidence 0.04 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10656608 Disease Relevance 0.35 Pain Relevance 0.51
This could be of importance if chronic administration of drugs does indeed increase basal activity of the mu receptor [16,33].
Positive_regulation (increase) of mu receptor
7) Confidence 0.03 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.14
The present study used the irreversible mu antagonist, beta-funaltrexamine (beta-FNA), to examine the role of mu receptor activation in this test. beta-FNA given intracranially 4 h before testing fully blocked the effects of morphine and attenuated the effects of ethylketocyclazocine and U50,488H.
Spec (examine) Positive_regulation (activation) of mu receptor associated with antagonist and morphine
8) Confidence 0.01 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1965514 Disease Relevance 0.27 Pain Relevance 0.80
A comparison of the findings from the conformational analysis and biological assays establishes that relatively extended structures, in which the two aromatic side chains are oriented in opposite directions with a approximately 14 A separation, is required for activity at the mu receptor.
Positive_regulation (required) of mu receptor
9) Confidence 0.00 Published 1991 Journal Biopolymers Section Abstract Doc Link 1655089 Disease Relevance 0 Pain Relevance 0.36
These findings suggest that mu-receptor activation not only acts on inhibitory neurons to disinhibit PAG output neurons but also interacts with TRPV1 activation at increasing glutamate release into the RVM, possibly by acting directly on PAG output neurons projecting to the RVM.
Positive_regulation (activation) of mu-receptor in RVM associated with glutamate, urological neuroanatomy and rostral ventromedial medulla
10) Confidence 0.00 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19297510 Disease Relevance 0.83 Pain Relevance 1.49

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