INT128230

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.77
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bone marrow 1
mast cell 1
tryptase (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 99.68 Very High Very High Very High
cINOD 2 99.24 Very High Very High Very High
pruritus 18 83.68 Quite High
depression 18 70.68 Quite High
cytokine 2 62.72 Quite High
chemokine 2 62.12 Quite High
Pain 22 52.76 Quite High
abdominal pain 2 46.88 Quite Low
headache 6 5.00 Very Low Very Low Very Low
Dysuria 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Mastocytosis 78 99.90 Very High Very High Very High
INFLAMMATION 20 99.68 Very High Very High Very High
Hypersensitivity 8 99.42 Very High Very High Very High
Cutaneous Mastocytosis 48 98.56 Very High Very High Very High
Asthma 4 96.96 Very High Very High Very High
Disease 36 95.52 Very High Very High Very High
Exanthema 2 92.88 High High
Urticaria Pigmentosa 2 92.24 High High
Occupational Lung Diseases 2 90.16 High High
Mastocytosis 178 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tryptase inhibitors: a novel class of anti-inflammatory drugs.
Negative_regulation (inhibitors) of Tryptase associated with inflammation and cinod
1) Confidence 0.57 Published 1997 Journal Expert Opin Investig Drugs Section Title Doc Link 15989643 Disease Relevance 1.01 Pain Relevance 0.32
Current data provide compelling evidence that tryptase plays a fundamental role in allergic inflammation, and selective tryptase inhibitors may represent a novel class of anti-inflammatory therapeutics for treating asthma and other mast cell-mediated diseases.
Negative_regulation (inhibitors) of tryptase in mast cell associated with asthma, inflammation, hypersensitivity and disease
2) Confidence 0.41 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989643 Disease Relevance 1.26 Pain Relevance 0.33
SM; Table 8), the presence or absence of the KIT D818V mutation (Table 9), or the presence or absence of a serum tryptase level ?
Negative_regulation (absence) of tryptase associated with systemic mastocytosis
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 1.10 Pain Relevance 0.11
Minor criteria for a diagnosis of SM can include abnormal mast cell morphologies in the bone marrow and other extracutaneous organs, mutation of the tyrosine kinase KIT at codon 816, expression of CD2 and/or CD25 by bone marrow mast cells, and a serum tryptase level >20 ng/mL.
Negative_regulation (include) of tryptase in bone marrow associated with systemic mastocytosis
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.40 Pain Relevance 0.12

General Comments

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