INT128269

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.06
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a7)
Anatomy Link Frequency
neuronal 1
parietal 1
Slc17a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 3 99.98 Very High Very High Very High
Glutamate 28 99.74 Very High Very High Very High
fluoxetine 4 99.44 Very High Very High Very High
antidepressant 28 99.32 Very High Very High Very High
Hippocampus 10 96.44 Very High Very High Very High
antagonist 19 95.16 Very High Very High Very High
depression 3 84.80 Quite High
Serotonin 3 78.48 Quite High
cerebral cortex 2 73.28 Quite High
noradrenaline 1 72.80 Quite High
Disease Link Frequency Relevance Heat
Psychosis 2 99.92 Very High Very High Very High
Depression 3 84.80 Quite High
Shock 4 80.16 Quite High
Serotonin Syndrome 1 78.84 Quite High
Disease 43 72.24 Quite High
Fever 1 71.44 Quite High
Catalepsy 2 64.88 Quite High
Cognitive Disorder 12 59.76 Quite High
Parkinson's Disease 6 59.36 Quite High
Anxiety Disorder 11 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated treatment with fluoxetine, paroxetine or desipramine increased VGLUT1 mRNA abundance in frontal, orbital, cingulate and parietal cortices, and regions of the hippocampus.
Positive_regulation (increased) of VGLUT1 in parietal associated with desipramine, hippocampus and fluoxetine
1) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.23 Pain Relevance 0.59
Given the importance of cortical neuronal activity in psychosis we investigated VGLUT1 mRNA and protein expression in response to chronic treatment with commonly prescribed psychotropic medications.
Spec (investigated) Positive_regulation (investigated) of VGLUT1 mRNA in neuronal associated with psychosis
2) Confidence 0.30 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16111724 Disease Relevance 0.22 Pain Relevance 0.37
Selective cortical VGLUT1 increase as a marker for antidepressant activity.
Positive_regulation (increase) of VGLUT1 associated with antidepressant
3) Confidence 0.25 Published 2005 Journal Neuropharmacology Section Title Doc Link 16111724 Disease Relevance 0.19 Pain Relevance 0.33
However, memantine (10 mg/kg i.p.) had no effect on the CNS expression pattern of the vesicular glutamate transporter VGLUT1, upregulation of which has been proposed to be a useful marker for antidepressant activity [178].
Positive_regulation (upregulation) of VGLUT1 associated with antidepressant and glutamate
4) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.43 Pain Relevance 0.53

General Comments

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