INT128273

Context Info Confidence 0.62 First Reported 2005 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.82 Pain Relevance 1.72

transmembrane transport (Slc17a7)

Anatomy Link Frequency brain 2 Slc17a7 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 68 100.00 antidepressant 16 100.00 Glutamate receptor 7 100.00 nMDA receptor 63 99.52 antagonist 22 98.20 fluoxetine 2 95.52 Desipramine 1 93.44 cytokine 6 89.32 Hippocampus 8 84.08 depression 4 83.68

Disease Link Frequency Relevance Heat Depression 4 83.68 Serotonin Syndrome 1 81.88 Leukemia 1 80.08 Fever 1 74.48 Shock 4 71.36 Disease 62 71.12 Catalepsy 2 63.76 Parkinson's Disease 6 58.24 Drug Induced Neurotoxicity 3 54.56 Ataxia 7 50.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study investigated the effect of antidepressant treatment on expression of the vesicular glutamate transporters, VGLUT1-3 in brain regions of the rat.

Spec (investigated) Regulation (effect) of Gene_expression (expression) of VGLUT1 in brain associated with glutamate and antidepressant

1) Confidence 0.62 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.20 Pain Relevance 0.55

Because our VGLUT1 data suggested that our IT-type terminal labeling method may have undercounted axospinous terminals in the 0.5 ?

Regulation (our) of Gene_expression (data) of VGLUT1

2) Confidence 0.37 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2982718 Disease Relevance 0 Pain Relevance 0.06

Expression of ionotropic glutamate receptor subunits NR2A, NR2B and GluR2, and of the vesicular glutamate transporter VGLUT1 was also previously shown not to be altered by CNTF [12].

Regulation (altered) of Gene_expression (Expression) of VGLUT1 associated with glutamate and glutamate receptor

3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.13 Pain Relevance 0.53

However, memantine (10 mg/kg i.p.) had no effect on the CNS expression pattern of the vesicular glutamate transporter VGLUT1, upregulation of which has been proposed to be a useful marker for antidepressant activity [178].

Neg (no) Regulation (effect) of Gene_expression (expression) of VGLUT1 associated with antidepressant and glutamate

4) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.48 Pain Relevance 0.57

General Comments

This test has worked.