INT128273

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.82
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a7)
Anatomy Link Frequency
brain 2
Slc17a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 68 100.00 Very High Very High Very High
antidepressant 16 100.00 Very High Very High Very High
Glutamate receptor 7 100.00 Very High Very High Very High
nMDA receptor 63 99.52 Very High Very High Very High
antagonist 22 98.20 Very High Very High Very High
fluoxetine 2 95.52 Very High Very High Very High
Desipramine 1 93.44 High High
cytokine 6 89.32 High High
Hippocampus 8 84.08 Quite High
depression 4 83.68 Quite High
Disease Link Frequency Relevance Heat
Depression 4 83.68 Quite High
Serotonin Syndrome 1 81.88 Quite High
Leukemia 1 80.08 Quite High
Fever 1 74.48 Quite High
Shock 4 71.36 Quite High
Disease 62 71.12 Quite High
Catalepsy 2 63.76 Quite High
Parkinson's Disease 6 58.24 Quite High
Drug Induced Neurotoxicity 3 54.56 Quite High
Ataxia 7 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the effect of antidepressant treatment on expression of the vesicular glutamate transporters, VGLUT1-3 in brain regions of the rat.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of VGLUT1 in brain associated with glutamate and antidepressant
1) Confidence 0.62 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.20 Pain Relevance 0.55
Because our VGLUT1 data suggested that our IT-type terminal labeling method may have undercounted axospinous terminals in the 0.5 ?
Regulation (our) of Gene_expression (data) of VGLUT1
2) Confidence 0.37 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2982718 Disease Relevance 0 Pain Relevance 0.06
Expression of ionotropic glutamate receptor subunits NR2A, NR2B and GluR2, and of the vesicular glutamate transporter VGLUT1 was also previously shown not to be altered by CNTF [12].
Regulation (altered) of Gene_expression (Expression) of VGLUT1 associated with glutamate and glutamate receptor
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.13 Pain Relevance 0.53
However, memantine (10 mg/kg i.p.) had no effect on the CNS expression pattern of the vesicular glutamate transporter VGLUT1, upregulation of which has been proposed to be a useful marker for antidepressant activity [178].
Neg (no) Regulation (effect) of Gene_expression (expression) of VGLUT1 associated with antidepressant and glutamate
4) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.48 Pain Relevance 0.57

General Comments

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