INT128285

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 96.12 Very High Very High Very High
qutenza 3 93.44 High High
Bioavailability 1 79.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 97.40 Very High Very High Very High
Cancer 4 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of these agents (EGCG, genistein, and curcumin) appear to directly target specific RTKs, and all of these compounds cause inhibition of the activity of the transcription factors AP-1 and NF-kappaB, thus inhibiting cell proliferation and enhancing apoptosis.
Negative_regulation (inhibition) of AP-1 Binding (activity) of associated with apoptosis
1) Confidence 0.38 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15992833 Disease Relevance 0.39 Pain Relevance 0.13
Binding of activator protein-1 (AP-1) to the 12-tetradecanoylphorbol-13-acetate-responsive element (TRE) sequence in LPS-stimulated cells was inhibited by bis-FA at 1 microM and dehydrodiisoeugenol at 0.1 microM, but not by the parent monomers isoeugenol and ferulic acid.
Negative_regulation (inhibited) of AP-1 Binding (Binding) of
2) Confidence 0.02 Published 2005 Journal In Vivo Section Abstract Doc Link 16277019 Disease Relevance 0 Pain Relevance 0.10

General Comments

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