INT128302

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 9.81
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 5
spinal cord 2
neuronal 2
PAG 1
striatum 1
NeuN (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 180 99.78 Very High Very High Very High
Dorsal horn neuron 15 99.56 Very High Very High Very High
Calcitonin gene-related peptide 18 99.10 Very High Very High Very High
spinal dorsal horn 28 98.32 Very High Very High Very High
substance P 14 98.14 Very High Very High Very High
ischemia 154 97.60 Very High Very High Very High
chung model 1 96.72 Very High Very High Very High
dorsal root ganglion 63 96.28 Very High Very High Very High
Spinal nerve ligature 2 95.84 Very High Very High Very High
Central nervous system 78 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 99.80 Very High Very High Very High
Cv General 4 Under Development 56 97.60 Very High Very High Very High
Cv Unclassified Under Development 91 97.28 Very High Very High Very High
Ganglion Cysts 203 96.28 Very High Very High Very High
Neuropathic Pain 34 94.40 High High
Stroke 37 91.92 High High
Diabetes Mellitus 122 91.84 High High
Inflammatory Pain 2 90.28 High High
Nociception 32 90.04 High High
Death 45 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary antibodies used were: rabbit anti-GFP, 1:500 (Invitrogen; Eugene, OR), guinea pig anti-SP; 1:500 (Neuromics; Edina, MN), rabbit anti-CGRP, 1:500 (Immunostar; Hudson, WI), mouse anti-NeuN. 1:500 (Chemicon; Temecula, CA), mouse anti-GFAP, 1:400 (Sigma; St.
Localization (1:500) of NeuN associated with calcitonin gene-related peptide and substance p
1) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0 Pain Relevance 0.17
To visualize the colocalization of BDNF with NeuN or GFAP, we performed double immunofluorescence on the SC sections from the NMDA-treated mice.
Localization (colocalization) of NeuN
2) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0
Colocalization of CFP and NeuN immunoreactivities was determined from confocal images of the GCL from five retinal wholemounts (Table 1).
Localization (Colocalization) of NeuN
3) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.33 Pain Relevance 0
NeuN immunoreactivity was localized to numerous cells in the proximal INL and GCL of varied size and intensity of immunostaining (Figure 5B,E).
Localization (localized) of NeuN in proximal
4) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.35 Pain Relevance 0
For spinal cord analysis, colocalization of GFP-Pde1c with NeuN, PKC?
Localization (colocalization) of NeuN in spinal cord associated with spinal cord
5) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0 Pain Relevance 0.15
All of these pERK-positive signals in dorsal horn neurons in injured mice were colocalized with NeuN signals, suggesting that they can be attributed to the activation of spinal neurons (Figure 4c).


Localization (colocalized) of NeuN in spinal associated with dorsal horn neuron
6) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2488330 Disease Relevance 0.32 Pain Relevance 0.31
In the DH, there was no obvious co-localization of TRPV1 with the neuronal marker NeuN, suggesting that the distribution of TRPV1 in DH is predominantly in fibers projecting from DRG rather than in the cell body of DH neurons.
Localization (localization) of NeuN in cell body associated with dorsal root ganglion
7) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.96 Pain Relevance 0.39
Furthermore, we found an increased number of BrdU/NeuN double-labeled cells in the SVZ and affected striatum of TGF-?
Localization (number) of NeuN in striatum
8) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2637876 Disease Relevance 0.54 Pain Relevance 0.10
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (used) of NeuN
9) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.03
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:500) of NeuN
10) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:500) of NeuN
11) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:1000) of NeuN
12) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.03
Morphological, anatomical correlation, and colocalization of TLR11 and Neun staining strongly suggested that the upregulated TLR11 expression was mainly in neurons (Fig. 2F).
Localization (colocalization) of Neun in neurons
13) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.34 Pain Relevance 0.03
Microwave pre-treatment for antigen retrieval was regularly performed with exception of the sections for the NeuN and glial fibrillary acidic protein (GFAP) stainings.
Localization (sections) of NeuN
14) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0.29 Pain Relevance 0.06
Colocalization for PAR and NeuN revealed that PAR formation in neurons was found maximal at 4 h of ischemia as compared to 24 h (Fig. 3B).
Localization (Colocalization) of NeuN in neurons associated with ischemia
15) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.86 Pain Relevance 0.39
NeuN stained sections were compared to ensure that the defined
Localization (sections) of NeuN
16) Confidence 0.18 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.12 Pain Relevance 0.04
Representative photomicrographs of stained hippocampal CA1 sections revealed that GCI induced a significant loss of hippocampal CA1 neurons at 7 d following ischemic reperfusion, as indicated by a significant decrease in NeuN-positive stained cells in saline-treated animals following GCI as compared to sham controls (Fig. 1B).
Localization (decrease) of NeuN in neurons associated with ischemia
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.74 Pain Relevance 0.28
Using immunostaining for caspase 3, NeuN, and GFAP, localization of apoptotic cells was observed.
Localization (localization) of NeuN in apoptotic cells
18) Confidence 0.12 Published 2008 Journal Spine Section Body Doc Link 18469688 Disease Relevance 0.05 Pain Relevance 0
Co-localisation of Fos with NeuN ascertained the neuronal nature of Fos-expressing cells at the spinal cord and PAG.
Localization (localisation) of NeuN in PAG associated with urological neuroanatomy and spinal cord
19) Confidence 0.12 Published 2010 Journal Eur J Pain Section Abstract Doc Link 20056558 Disease Relevance 1.74 Pain Relevance 0.95
Although there were positive reactions for cleaved caspase-3 or p53 in the septal nucleus after axotomy, they did not co-localize with ChAT, p75 or the general neuronal marker NeuN (Figure 4A, B, C).
Neg (not) Localization (localize) of NeuN in neuronal
20) Confidence 0.10 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.50 Pain Relevance 0.09

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