INT128304

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.30
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cx3cl1) extracellular region (Cx3cl1) plasma membrane (Cx3cl1)
cytoplasm (Cx3cl1)
Anatomy Link Frequency
microglia 4
astrocytes 2
Cx3cl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
neuralgia 4 100.00 Very High Very High Very High
Neuritis 3 99.84 Very High Very High Very High
Spinal cord 9 99.76 Very High Very High Very High
Dorsal horn 3 99.00 Very High Very High Very High
Neuropathic pain 6 96.96 Very High Very High Very High
Pain 2 95.76 Very High Very High Very High
allodynia 2 95.60 Very High Very High Very High
Lasting pain 2 92.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.92 Very High Very High Very High
Experimental Autoimmune Neuritis 3 99.84 Very High Very High Very High
Nervous System Injury 4 99.26 Very High Very High Very High
Neuropathic Pain 8 96.96 Very High Very High Very High
Pain 4 95.76 Very High Very High Very High
Inflammatory Pain 2 85.16 High High
Disease 1 84.80 Quite High
Syndrome 2 83.48 Quite High
Hypersensitivity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain.
Positive_regulation (Induction) of Gene_expression (expression) of CX3CL1 in astrocytes associated with inflammation, neuropathic pain and spinal cord
1) Confidence 0.70 Published 2005 Journal J Pain Section Title Doc Link 15993821 Disease Relevance 0.58 Pain Relevance 1.06
The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.
Positive_regulation (higher) of Gene_expression (expression) of CX3CL1 in microglia associated with pain, chemokine and neuritis
2) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18448252 Disease Relevance 1.06 Pain Relevance 0.89
PERSPECTIVE: This study shows that spinal nerve injury, but not peripheral inflammation, induces the expression of a chemokine, CX3CL1 (fractalkine), in astrocytes and upregulates CX3CR1 in microglia in the spinal cord.
Positive_regulation (duces t) of Gene_expression (pression o) of CX3CL1 in microglia associated with chemokine, nervous system injury, inflammation and spinal cord
3) Confidence 0.41 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.66 Pain Relevance 0.90

General Comments

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