INT128315

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Npas2) nucleus (Npas2) DNA binding (Npas2)
cytoplasm (Npas2) signal transducer activity (Npas2)
Anatomy Link Frequency
neuronal 2
Npas2 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 8 99.72 Very High Very High Very High
fluoxetine 8 99.08 Very High Very High Very High
antidepressant 4 98.86 Very High Very High Very High
Serotonin 4 98.60 Very High Very High Very High
Hippocampus 6 88.64 High High
addiction 2 86.52 High High
endometriosis 3 57.68 Quite High
depression 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 17 98.44 Very High Very High Very High
Drug Dependence 2 86.52 High High
Sleep Disorders 26 81.60 Quite High
Endometriosis (extended) 4 57.68 Quite High
Affective Disorder 2 47.12 Quite Low
Targeted Disruption 7 24.76 Low Low
Aging 1 22.16 Low Low
Disease 5 10.88 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Gene_expression (expression) of NPAS2 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
1) Confidence 0.74 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.68
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Gene_expression (expression) of neuronal PAS domain protein 2 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
2) Confidence 0.74 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.69
The expression of three different polymorphisms of the NPAS2 gene was examined in control (n = 476) and breast cancer cases (n = 431).
Spec (examined) Gene_expression (expression) of NPAS2 gene associated with breast cancer
3) Confidence 0.25 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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