INT128316

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.68
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arntl) nucleus (Arntl) DNA binding (Arntl)
transcription factor binding (Arntl) cytoplasm (Arntl) signal transducer activity (Arntl)
Anatomy Link Frequency
neuronal 2
blood vessels 2
liver 2
Arntl (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 4 100.00 Very High Very High Very High
cocaine 4 100.00 Very High Very High Very High
antidepressant 2 100.00 Very High Very High Very High
tetrodotoxin 8 99.84 Very High Very High Very High
Serotonin 2 95.72 Very High Very High Very High
addiction 1 92.08 High High
agonist 25 84.68 Quite High
Hippocampus 9 82.88 Quite High
Eae 8 77.84 Quite High
adenocard 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 92.08 High High
Sleep Disorders 84 86.36 High High
Disease 26 80.24 Quite High
Stress 19 73.36 Quite High
Repression 10 67.68 Quite High
Aging 27 52.72 Quite High
Targeted Disruption 5 44.72 Quite Low
Metabolic Syndrome 27 23.76 Low Low
Obesity 25 5.00 Very Low Very Low Very Low
Cognitive Disorder 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
at Bmal1 promoter to repress Bmal1 expression in liver in a Rev-erb?
Regulation (liver) of Gene_expression (expression) of Bmal1 in liver
1) Confidence 0.43 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.07 Pain Relevance 0
appears to be a major regulator of Bmal1 expression in blood vessels.
Regulation (regulator) of Gene_expression (expression) of Bmal1 in blood vessels
2) Confidence 0.43 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04
sites on BMAL1, we focused our attention on two loci which contained multiple GSK3?
Regulation (focused) of Gene_expression (sites) of BMAL1
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Bmal1 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
4) Confidence 0.30 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.65
The circadian rhythms in the expression of clock genes, Per1, Per2, Bmal1 and Cry1, and of clock-associated genes, Dec1, Dec2, Rev-erbalpha, Rev-erbbeta and DBP, were not affected by TTX treatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of Bmal1 associated with tetrodotoxin
5) Confidence 0.27 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.70
Alteration in circadian expression pattern of vascular Bmal1 has been observed in these mice [30], implicating the involvement of Bmal1 in cardiovascular physiology.
Regulation (Alteration) of Gene_expression (expression) of Bmal1
6) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.46 Pain Relevance 0.04
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
Regulation (alters) of Gene_expression (expression) of BMAL1
7) Confidence 0.05 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0

General Comments

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