INT128319

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 105
Total Number 109
Disease Relevance 14.69
Pain Relevance 15.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Anatomy Link Frequency
retinas 4
inner nuclear layer 4
ependymal cell 3
third ventricle 3
fat 2
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 3483 100.00 Very High Very High Very High
cocaine 5 99.72 Very High Very High Very High
agonist 772 99.46 Very High Very High Very High
GABAergic 365 99.16 Very High Very High Very High
Dopamine 2049 99.08 Very High Very High Very High
fluoxetine 14 99.08 Very High Very High Very High
Action potential 575 99.04 Very High Very High Very High
antidepressant 22 98.86 Very High Very High Very High
imagery 456 98.84 Very High Very High Very High
GABA receptor 243 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 2560 99.68 Very High Very High Very High
Shock 142 99.12 Very High Very High Very High
Repression 38 98.16 Very High Very High Very High
Ganglion Cysts 718 98.00 Very High Very High Very High
Breast Cancer 51 98.00 Very High Very High Very High
Endometriosis (extended) 12 95.32 Very High Very High Very High
Opiate Addiction 2 93.44 High High
Fever 4 92.76 High High
Morphine Dependence 4 92.12 High High
Sleep Disorders 118 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data are consistent with these results (Figure 1D and Figure 2C) and expand on the previous investigations by showing that Per2 gene expression is under circadian control in the RPE in vivo, and that isolated RPE-choroid explants can express a long-lasting circadian rhythm in PER2::LUC bioluminescence.
Gene_expression (expression) of Per2 in choroid
1) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0.06 Pain Relevance 0.03
No overt PER2::LUC expression was seen in the VMH in any MBH slice (Figs. 1 and 2), and measures of background bioluminescence revealed no rhythm of PER2::LUC bioluminescence in this region (Fig. 2A and 2B).
Gene_expression (expression) of PER2
2) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.24 Pain Relevance 0
Damped PER2::LUC expression in tissue explants from food deprived (and control mice) was consistently restarted by the addition of KCl, a potent depolarizing stimulus, to the culture medium (additional file 1, Fig.
Gene_expression (expression) of PER2
3) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.44 Pain Relevance 0
Previous investigations of per2/PER2 expression in the DMH in vivo under ad libitum feeding conditions revealed either a lack of expression [42], constitutively low expression [59-61] or very low amplitude rhythms [36].
Gene_expression (expression) of per2
4) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.31 Pain Relevance 0.09
PER2::LUC expression showed significant circadian rhythmicity in all regions in which it was visualized (Fig. 2; also see additional files 2 and 3: Movies 1 and 2; significance determined by Clockwise rhythm analysis software; p < 0.05 required for significance).
Gene_expression (expression) of PER2
5) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.31 Pain Relevance 0
PER2::LUC expression was observed in the ependymal cell layer surrounding the third ventricle (Figs. 1 and 2).
Gene_expression (expression) of PER2 in third ventricle
6) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.07 Pain Relevance 0
To assess whether the rhythmicity in the Arc complex (Arc/ME/PT) and DMH were dependent on interconnections between these nuclei preserved in whole slice cultures, and to further determine the circadian characteristics of these tissues, we performed long term analysis of PER2::LUC expression recorded in photomultiplier tube assemblies (PMTs); firstly from slice cultures consisting of a coronal section of intact MBH, then from micro-dissected, independently cultured, Arc complex and DMH (Fig. 5A and 5B; Table 1).
Gene_expression (expression) of PER2 in tube associated with aids-related complex
7) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.50 Pain Relevance 0
Peak PER2::LUC expression in the whole Arc was observed 28.6 ± 0.3 h after cull.
Gene_expression (expression) of PER2 associated with aids-related complex
8) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 1.23 Pain Relevance 0
Previous investigations of per2/PER2 expression in the DMH in vivo under ad libitum feeding conditions revealed either a lack of expression [42], constitutively low expression [59-61] or very low amplitude rhythms [36].
Gene_expression (expression) of PER2
9) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.31 Pain Relevance 0.09
Here, we localize endogenous PER2 expression to the ME/PT and ependymal cell layer and, importantly, discriminate single cells in the ArcD, ArcL and DMHc.
Gene_expression (expression) of PER2 in ependymal cell associated with aids-related complex
10) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.32 Pain Relevance 0
Circadian rhythms of PER2::LUC expression imaged in the SCN
Gene_expression (expression) of PER2
11) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.15 Pain Relevance 0
PER2::LUC expression generally appeared after the initial first peak of the Arc and DMH and appeared to travel bi-directionally: down from the top of the third ventricle, and up from the base of the ME in a wave like pattern (see additional files 2 and 3: Movies 1 and 2).
Gene_expression (expression) of PER2 in third ventricle associated with aids-related complex
12) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.16 Pain Relevance 0
Our observation that overnight food deprivation does not alter DMH PER2 expression in vitro is in agreement with results obtained in vivo [36].
Gene_expression (expression) of PER2
13) Confidence 0.77 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.08 Pain Relevance 0.18
agonist, bezafibrate, was shown to stimulate phase advancement of Per2 circadian expression in peripheral tissues [29].
Gene_expression (expression) of Per2 associated with agonist
14) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.09
In the MHb, very weakly rhythmic temporal expression of PER2::LUC bioluminescence was observed in 5 of 11 cultures, and appeared linked to the waves of expression radiating up the ependymal cell layer (period 24±0.9 h; Movie 1, Figs. 3 and 4), and hence may reflect expression in ependymal tanycytes projecting into this structure (Cupedo and de Weerd, 1985).
Gene_expression (expression) of PER2 in tanycytes
15) Confidence 0.71 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0
To determine if rhythmic expression of PER2::LUC in the Hb was accompanied by circadian variation in spontaneous discharge activity, population and single cell electrical activity were recorded extracellularly in the LHbM for at least 48 h in vitro.
Gene_expression (expression) of PER2
16) Confidence 0.71 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0.03
We demonstrate for the first time that PER2 is rhythmically expressed in the LHb in mouse, and that this expression shows clear circadian variation and persists in isolation from the SCN.
Gene_expression (expressed) of PER2
17) Confidence 0.71 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0
Ependymal cells lining the dorsal third ventricle also express circadian oscillations of PER2.
Gene_expression (express) of PER2 in third ventricle
18) Confidence 0.71 Published 2010 Journal Neuroscience Section Abstract Doc Link PMC2928449 Disease Relevance 0.06 Pain Relevance 0.18
While one study has noted the presence of per1 and per2 mRNA in the rat MHb (Shieh, 2003), only one published study has investigated clock gene protein expression in the Hb, and did not detect either PER1 or PER2 protein expression in the hamster Hb (Tavakoli-Nezhad and Schwartz, 2006).
Gene_expression (expression) of PER2
19) Confidence 0.71 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0
Disruption of per2 expression was reported to result in reduced transcription levels of other clock genes, whereas PER1 appears to act predominantly at the posttranscriptional level [16].
Gene_expression (expression) of per2
20) Confidence 0.68 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0

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