INT12832

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.13
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
Leydig cells 2
striatum 2
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
Opioid 3 99.74 Very High Very High Very High
dopamine receptor 20 99.36 Very High Very High Very High
opiate 1 97.20 Very High Very High Very High
agonist 1 96.78 Very High Very High Very High
antagonist 3 88.96 High High
noradrenaline 1 88.76 High High
dexamethasone 2 87.16 High High
monoamine 1 84.00 Quite High
Glutamate receptor 3 83.12 Quite High
Disease Link Frequency Relevance Heat
Stress 12 99.98 Very High Very High Very High
Disease 1 75.00 Quite High
Parkinson's Disease 3 55.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that noradrenergic pathways are not involved in maintaining basal levels of CRF mRNA and that the noradrenergic input through the VNAB does not mediate the accumulation of CRF and proenkephalin A mRNAs in response to these stressors.
Neg (not) Positive_regulation (mediate) of Positive_regulation (accumulation) of proenkephalin A
1) Confidence 0.67 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.48 Pain Relevance 0.16
Differential effects were induced by agonists of the group II mGluRs, viz. (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine administered intraventricularly (3 times at 0.1-0.2 microg/4 microl, 3 h apart) increased both the normal and haloperidol-increased proenkephalin mRNA level, whereas (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate injected intrastriatally (3 times at 15 microg/0.5 microl, 3 h apart) was ineffective.
Positive_regulation (increased) of Positive_regulation (haloperidol-increased) of proenkephalin associated with agonist
2) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 14622918 Disease Relevance 0.13 Pain Relevance 0.30
BACKGROUND: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth.
Positive_regulation (effects) of Positive_regulation (derived) of proenkephalin-A associated with enkephalin and opioid
3) Confidence 0.49 Published 2006 Journal Eur Surg Res Section Abstract Doc Link 16940731 Disease Relevance 0 Pain Relevance 0.30
Treatment of cultured Leydig cells with hCG or a cAMP analog leads to a rapid increase in proenkephalin-mRNA levels.
Positive_regulation (leads) of Positive_regulation (increase) of proenkephalin in Leydig cells
4) Confidence 0.45 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2560809 Disease Relevance 0 Pain Relevance 0.08
Furthermore the data demonstrates a steroid-sensitive stress mediated increase in proenkephalin A mRNA which provides additional evidence for a role of the endogenous opiates in the hypothalamic neuroendocrine response to stress.
Positive_regulation (mediated) of Positive_regulation (increase) of proenkephalin A associated with stress and opiate
5) Confidence 0.45 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.52 Pain Relevance 0.18
At birth, high levels of enkephalin mRNA were restricted to the matrix; D1R mRNA level was homogeneous throughout the striatum.
Positive_regulation (restricted) of Positive_regulation (levels) of enkephalin mRNA in striatum associated with dopamine receptor and enkephalin
6) Confidence 0.34 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 1.12

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