INT128320

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Npas2) nucleus (Npas2) DNA binding (Npas2)
cytoplasm (Npas2) signal transducer activity (Npas2)
Anatomy Link Frequency
neuronal 4
Npas2 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 8 100.00 Very High Very High Very High
cocaine 8 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
Serotonin 4 98.60 Very High Very High Very High
addiction 2 92.08 High High
Hippocampus 6 88.64 High High
Disease Link Frequency Relevance Heat
Drug Dependence 2 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of neuronal PAS domain protein 2 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
1) Confidence 0.43 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.69
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of NPAS2 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
2) Confidence 0.43 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.69

General Comments

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