INT128321

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.09
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cry1) nucleus (Cry1) protein binding transcription factor activity (Cry1)
cytoplasm (Cry1)
Anatomy Link Frequency
neuronal 2
Cry1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 4 100.00 Very High Very High Very High
cocaine 4 100.00 Very High Very High Very High
antidepressant 2 100.00 Very High Very High Very High
tetrodotoxin 8 99.84 Very High Very High Very High
Serotonin 2 96.32 Very High Very High Very High
addiction 1 92.08 High High
Hippocampus 3 84.08 Quite High
Pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 92.08 High High
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Duodenal Ulcer 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The circadian rhythms in the expression of clock genes, Per1, Per2, Bmal1 and Cry1, and of clock-associated genes, Dec1, Dec2, Rev-erbalpha, Rev-erbbeta and DBP, were not affected by TTX treatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of Cry1 associated with tetrodotoxin
1) Confidence 0.34 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.70
represses bmal1 expression, and regulates clock and cry1 expression [8].
Regulation (regulates) of Gene_expression (expression) of cry1
2) Confidence 0.20 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Cryptochrome1 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
3) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.68

General Comments

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