INT128324

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 1.95
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) nucleus (Per1) protein binding transcription factor activity (Per1)
cytoplasm (Per1) signal transducer activity (Per1)
Anatomy Link Frequency
brain 5
kidney 3
neuronal 2
skeletal muscle 2
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 11 100.00 Very High Very High Very High
fluoxetine 4 100.00 Very High Very High Very High
antidepressant 2 100.00 Very High Very High Very High
imagery 12 99.92 Very High Very High Very High
tetrodotoxin 9 99.84 Very High Very High Very High
Morphine 167 99.66 Very High Very High Very High
addiction 41 98.40 Very High Very High Very High
withdrawal 115 97.68 Very High Very High Very High
Serotonin 2 94.44 High High
Hippocampus 9 80.32 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 129 99.28 Very High Very High Very High
Morphine Dependence 20 98.64 Very High Very High Very High
Death 4 94.84 High High
Drug Dependence 19 92.08 High High
Muscle Disease 29 90.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 89.40 High High
Sleep Disorders 10 87.32 High High
Stress 28 83.80 Quite High
Apoptosis 15 78.44 Quite High
Tendinopathy 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we sought to investigate whether morphine treatment could alter the expression of mPer1, especially in brain regions outside the SCN and in peripheral tissues.
Regulation (alter) of Gene_expression (expression) of mPer1 in brain associated with morphine
1) Confidence 0.61 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.24 Pain Relevance 0.64
OBJECTIVE: To investigate the regulatory effects of deoxyribozyme on the expression of Period 1 gene in vitro and on the morphine-induced psychic dependence in mice.
Spec (investigate) Regulation (effects) of Gene_expression (expression) of Period 1 associated with addiction and morphine
2) Confidence 0.59 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 17037739 Disease Relevance 0 Pain Relevance 0.26
In contrast to mPER1 expression in the brain, the circadian rhythm of mPER1 immunoreactivity in the kidneys was abolished after morphine administration, whereas the Con mice maintained robust circadian rhythmicity of mPER1 in the kidney.
Regulation (contrast) of Gene_expression (expression) of mPER1 in kidney associated with morphine
3) Confidence 0.45 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.20 Pain Relevance 0.75
The circadian rhythms in the expression of clock genes, Per1, Per2, Bmal1 and Cry1, and of clock-associated genes, Dec1, Dec2, Rev-erbalpha, Rev-erbbeta and DBP, were not affected by TTX treatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of Per1 associated with tetrodotoxin
4) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.70
Of this group, Egr3 showed a significant increase in expression following the light pulse but no significant difference in Per1 or Per2 expression was detected.
Neg (no) Regulation (difference) of Gene_expression (expression) of Per1
5) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0
In Con mice, mPER1 protein expression showed a peak at 3:11, whereas the peak value of mPER1 protein expression was not obviously noticed after morphine administration.
Regulation (value) of Gene_expression (expression) of mPER1 protein associated with morphine
6) Confidence 0.27 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.46
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal

Every physiological function in the human body exhibits some form of circadian rhythmicity.

Regulation (Altered) of Gene_expression (expression) of mPer1 in brain associated with addiction, withdrawal and morphine
7) Confidence 0.27 Published 2006 Journal J Circadian Rhythms Section Title Doc Link PMC1563481 Disease Relevance 0.28 Pain Relevance 0.53
Live imaging of altered period1 expression in the suprachiasmatic nuclei of Vipr2?
Regulation (altered) of Gene_expression (expression) of period1 associated with imagery
8) Confidence 0.27 Published 2008 Journal Journal of Neurochemistry Section Title Doc Link PMC2658715 Disease Relevance 0 Pain Relevance 0.09
In the present study, we applied DNAzyme targeting mPer1 to interfere the expression of mPer1 in CNS in mice, and studied its effects on morphine-induced reward and its molecular mechanism.
Regulation (targeting) of Gene_expression (expression) of mPer1 associated with morphine
9) Confidence 0.19 Published 2007 Journal Neuroscience Section Abstract Doc Link 17320300 Disease Relevance 0.16 Pain Relevance 0.62
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal

Every physiological function in the human body exhibits some form of circadian rhythmicity.

Regulation (Altered) of in kidney Gene_expression (expression) of mPer1 in brain associated with addiction, withdrawal and morphine
10) Confidence 0.09 Published 2006 Journal J Circadian Rhythms Section Title Doc Link PMC1563481 Disease Relevance 0.28 Pain Relevance 0.53
These data therefore suggested that the expression of the Comp mutation per se did not have a generalized effect on the myocytes of skeletal muscle.


Regulation (effect) of Gene_expression (expression) of per se in skeletal muscle
11) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.39 Pain Relevance 0
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Period1 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
12) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.64
These mutations affect proinsulin biosynthesis per se and function as null mutations, doing so by several different mechanisms.
Regulation (affect) of Gene_expression (biosynthesis) of per se
13) Confidence 0.01 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.31 Pain Relevance 0

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