INT128327

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.11
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Anatomy Link Frequency
neuronal 2
fat 2
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 4 100.00 Very High Very High Very High
cocaine 4 100.00 Very High Very High Very High
antidepressant 2 100.00 Very High Very High Very High
tetrodotoxin 86 99.84 Very High Very High Very High
agonist 8 99.80 Very High Very High Very High
Eae 7 95.12 Very High Very High Very High
Serotonin 2 94.80 High High
addiction 7 92.08 High High
Hippocampus 10 81.04 Quite High
sodium channel 30 53.36 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 480 96.64 Very High Very High Very High
Drug Dependence 1 92.08 High High
Weight Gain 7 83.32 Quite High
Body Weight 13 83.12 Quite High
Obesity 9 61.28 Quite High
Weight Loss 6 32.64 Quite Low
Dislocations 13 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 12 5.00 Very Low Very Low Very Low
Metabolic Syndrome 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation that overnight food deprivation does not alter DMH PER2 expression in vitro is in agreement with results obtained in vivo [36].
Neg (not) Regulation (alter) of Gene_expression (expression) of PER2
1) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.08 Pain Relevance 0.18
No overt PER2::LUC expression was seen in the VMH in any MBH slice (Figs. 1 and 2), and measures of background bioluminescence revealed no rhythm of PER2::LUC bioluminescence in this region (Fig. 2A and 2B).
Regulation (seen) of Gene_expression (expression) of PER2
2) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.24 Pain Relevance 0
We observed no significant change in PER2::LUC expression in the MBH of HFF mice.
Neg (no) Regulation (change) of Gene_expression (expression) of PER2
3) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.10 Pain Relevance 0.04
PER2::LUC expression was observed in the ME/PT in all MBH slices and was often clearly delineated in the PT region.
Regulation (observed) of Gene_expression (expression) of PER2
4) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0 Pain Relevance 0
Of this group, Egr3 showed a significant increase in expression following the light pulse but no significant difference in Per1 or Per2 expression was detected.
Neg (no) Regulation (difference) of Gene_expression (expression) of Per2
5) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0
The circadian rhythms in the expression of clock genes, Per1, Per2, Bmal1 and Cry1, and of clock-associated genes, Dec1, Dec2, Rev-erbalpha, Rev-erbbeta and DBP, were not affected by TTX treatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of Per2 associated with tetrodotoxin
6) Confidence 0.36 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.70
These data indicate that changes in the hypothalamic expression of PER2 are not overtly involved in the etiology of circadian disruption associated with the ingestion of a diet rich in fat [21,47].


Regulation (changes) of Gene_expression (expression) of PER2 in fat
7) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.46 Pain Relevance 0
Despite this, we observed no feeding induced change in the expression of PER2 in the SCN.
Neg (no) Regulation (change) of Gene_expression (expression) of PER2
8) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.14 Pain Relevance 0.05
agonist, did not affect circadian expression of Per2, a core clock gene, in the SCN [29].
Regulation (affect) of Gene_expression (expression) of Per2 associated with agonist
9) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.05
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Period2 in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
10) Confidence 0.06 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.64

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