INT12833

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Context Info
Confidence 0.27
First Reported 1991
Last Reported 1994
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.32
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
nucleus 4
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 3 99.00 Very High Very High Very High
Catecholamine 6 96.28 Very High Very High Very High
Calcium channel 1 78.80 Quite High
monoamine 3 65.92 Quite High
Enkephalin 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 18 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the biochemical and molecular mechanisms involved in transcriptional regulation of the corticotropin-releasing hormone (CRH) gene by depolarization were investigated.
Regulation (involved) of Regulation (regulation) of CRH
1) Confidence 0.27 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.04
Depletion of endogenous noradrenaline following unilateral lesions of the VNAB did not affect the CRF mRNA or the proenkephalin A mRNA response to stress.
Neg (not) Regulation (affect) of Regulation (response) of CRF associated with stress and noradrenaline
2) Confidence 0.20 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.50 Pain Relevance 0.16
We have investigated the effects of unilateral ventral noradrenergic bundle (VNAB) lesions on corticotrophin-releasing factor (CRF) and proenkephalin A mRNA responses in the parvocellular paraventricular nucleus (pPVN) to both physical and psychological stresses.
Spec (investigated) Regulation (effects) of Regulation (responses) of corticotrophin-releasing factor in nucleus associated with stress
3) Confidence 0.14 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.41 Pain Relevance 0.12
We have investigated the effects of unilateral ventral noradrenergic bundle (VNAB) lesions on corticotrophin-releasing factor (CRF) and proenkephalin A mRNA responses in the parvocellular paraventricular nucleus (pPVN) to both physical and psychological stresses.
Spec (investigated) Regulation (effects) of Regulation (responses) of CRF in nucleus associated with stress
4) Confidence 0.14 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.41 Pain Relevance 0.12

General Comments

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