INT12834

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.00
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
cervix 6
plasma 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 97.80 Very High Very High Very High
noradrenaline 1 97.52 Very High Very High Very High
Catecholamine 2 77.72 Quite High
monoamine 1 53.92 Quite High
Enkephalin 2 25.00 Low Low
corticosteroid 15 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 98.40 Very High Very High Very High
Pre-term Labor 30 97.20 Very High Very High Very High
Premature Birth 33 5.00 Very Low Very Low Very Low
Reprotox - General 1 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Asphyxia 3 5.00 Very Low Very Low Very Low
Emergencies 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Breech Presentation 3 5.00 Very Low Very Low Very Low
Eclampsia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As in the case of both CRH-BP and CRH-R1 mRNA, the CRH-R2 mRNA level was generally higher in the non-pregnant cervix and these differences with respect to the PTL (p = 0.02) and TL (p = 0.002) groups were statistically significant (Figure 1C).
Positive_regulation (higher) of Transcription (level) of CRH in cervix associated with pre-term labor
1) Confidence 0.67 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.18 Pain Relevance 0
As in the case of both CRH-BP and CRH-R1 mRNA, the CRH-R2 mRNA level was generally higher in the non-pregnant cervix and these differences with respect to the PTL (p = 0.02) and TL (p = 0.002) groups were statistically significant (Figure 1C).
Positive_regulation (higher) of Transcription (level) of CRH in cervix associated with pre-term labor
2) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.18 Pain Relevance 0
RNase protection assays demonstrated increased levels of CRH-reporter transcripts in stably transfected cells after treatment with cAMP and potassium, with the induced transcripts initiating at the major transcription initiation site of the human CRH gene.
Positive_regulation (increased) of Transcription (transcripts) of CRH-reporter
3) Confidence 0.46 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.05
The CRH-R1 mRNA expression was significantly higher in the non-pregnant cervix compared to the pregnant cervix not in labor (p < 0.01) and in labor (p < 0.01) (data not shown).


Positive_regulation (higher) of Transcription (expression) of CRH in cervix
4) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.16 Pain Relevance 0
We have also determined the effects of direct bilateral PVN lesions on CRF mRNA, plasma ACTH and corticosterone responses to psychological stress. 6-OHDA lesions whether to the VNAB or direct to the PVN did not result in any change in basal levels of CRF mRNA.
Positive_regulation (change) of Transcription (levels) of CRF in plasma associated with stress
5) Confidence 0.15 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.49 Pain Relevance 0.15

General Comments

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