INT12835

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.15
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
PVN 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 90 100.00 Very High Very High Very High
depression 11 100.00 Very High Very High Very High
Morphine 4 99.80 Very High Very High Very High
dexamethasone 6 98.16 Very High Very High Very High
cva 6 97.64 Very High Very High Very High
monoamine 2 92.64 High High
narcan 6 91.08 High High
noradrenaline 1 83.72 Quite High
corticosteroid 1 82.44 Quite High
opiate 2 75.52 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 89 100.00 Very High Very High Very High
Stress 33 100.00 Very High Very High Very High
Depression 11 100.00 Very High Very High Very High
Anxiety Disorder 6 100.00 Very High Very High Very High
Hypoglycemia 1 98.20 Very High Very High Very High
Hemorrhage 6 97.64 Very High Very High Very High
Catatonia 1 95.76 Very High Very High Very High
Nicotine Addiction 9 69.04 Quite High
Rupture 2 52.88 Quite High
Syncope 1 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extrapolation of these concepts suggests that elevated CRH may be related to anxiety, depression, or other disorders associated with chronic stress responses.
Negative_regulation (depression) of Positive_regulation (elevated) of CRH associated with stress, depression and anxiety disorder
1) Confidence 0.42 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC544567 Disease Relevance 0.68 Pain Relevance 0.20
Investigators found normal to reduced cortisol levels in patients with FM after an increase in corticotropin-releasing hormone, but these results were not reproduced in other similar studies.
Negative_regulation (reduced) of Positive_regulation (increase) of corticotropin-releasing hormone associated with fibrositis
2) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 0.65 Pain Relevance 0.37
Oral morphine not only suppressed basal hormone levels (P less than 0.02), but also the peak response to hCRH compared with placebo (cortisol: 270 +/- 50 vs 559 +/- 80 nmol/l; ACTH: 5.1 +/- 1.5 vs 13.1 +/- 2.7 pmol/l; ir beta-endorphin: 48.5 +/- 8.7 vs 88 +/- 14 pmol/l; mean +/- SEM, P less than 0.02).
Negative_regulation (suppressed) of Positive_regulation (response) of hCRH associated with morphine
3) Confidence 0.34 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3033966 Disease Relevance 0 Pain Relevance 0.61
However, unilateral implants of dexamethasone significantly decreased basal CRF mRNA compared to the contralateral, unimplanted side and prevented the increase in CRF and proenkephalin A mRNA 4 hours after ip hypertonic saline stress.
Negative_regulation (prevented) of Positive_regulation (increase) of CRF associated with stress and dexamethasone
4) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.43 Pain Relevance 0.17
Unilateral implants of cholesterol directly over the PVN had no effect on either basal or stress-induced increase of CRF and proenkephalin A message.
Negative_regulation (stress-induced) of Positive_regulation (increase) of CRF in PVN associated with stress
5) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.41 Pain Relevance 0.15
If CRHBP does not function appropriately it may prevent the inactivation of CRH, causing the release of tPA and the activation of stress related response.
Spec (may) Negative_regulation (prevent) of Positive_regulation (inactivation) of CRH associated with stress
6) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.50 Pain Relevance 0.11
Direct bilateral lesions to the PVN prevented the accumulation of CRF mRNA but not the ACTH and corticosterone responses to restraint stress.
Negative_regulation (prevented) of Positive_regulation (accumulation) of CRF associated with stress
7) Confidence 0.19 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.47 Pain Relevance 0.15

General Comments

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