INT128353

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.93
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
hippocampus 2
pyramidal neurons 2
cortex 2
bars 1
dentate gyrus 1
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 235 99.96 Very High Very High Very High
nMDA receptor 229 99.96 Very High Very High Very High
Hippocampus 233 99.70 Very High Very High Very High
Morphine 10 98.16 Very High Very High Very High
Action potential 34 96.56 Very High Very High Very High
addiction 7 88.88 High High
GABAergic 54 87.72 High High
ketamine 23 83.24 Quite High
gABA 13 75.76 Quite High
Intracerebroventricular 5 63.44 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 141 100.00 Very High Very High Very High
Brain Injury 8 98.76 Very High Very High Very High
Epilepsy 23 98.60 Very High Very High Very High
Injury 77 98.24 Very High Very High Very High
Convulsion 164 97.48 Very High Very High Very High
Urological Neuroanatomy 10 96.84 Very High Very High Very High
Sclerosis 2 96.38 Very High Very High Very High
Aging 69 95.20 Very High Very High Very High
Cognitive Disorder 132 94.60 High High
Disease 45 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, pharmacological blockade of CA3 NMDA receptors enhanced the susceptibility to kainate-induced seizures.
Negative_regulation (blockade) of CA3 associated with convulsion and nmda receptor
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2615205 Disease Relevance 0.22 Pain Relevance 0.39
In the CA3 region of the hippocampus, peri-somatic inhibition of CA3 pyramidal neurons appears to dictate the time window during which these neurons fire action potentials (Hajos et al., 2004; Mann et al., 2005).
Negative_regulation (inhibition) of CA3 in neurons associated with action potential, pyramidal cell and hippocampus
2) Confidence 0.33 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.12 Pain Relevance 0.60
These results suggest that the NMDA receptor-slow AHP coupling is diminished in the hippocampal CA3 pyramidal neurons of mutant mice, which may result in enhanced excitability of the CA3 recurrent network as a whole.
Negative_regulation (diminished) of CA3 in pyramidal neurons associated with pyramidal cell and nmda receptor
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.29
We generated mutant mice in which NMDA receptors were abolished in hippocampal CA3 pyramidal neurons by postnatal day 14.
Negative_regulation (abolished) of CA3 in pyramidal neurons associated with pyramidal cell and nmda receptor
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2615205 Disease Relevance 0.17 Pain Relevance 0.25
Hippocampal sclerosis, a pattern of neuronal loss in vulnerable mesial structures of the temporal lobe, is found in about 70% of TLE patients [1], [2], and is characterized by severe segmental neuronal loss in the hippocampal subfields CA1, CA3, and the hilar region [3], [4].
Negative_regulation (loss) of CA3 in temporal lobe associated with epilepsy and sclerosis
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.72 Pain Relevance 0.03
34.4, P<0.05; 45% decrease for CA2-3: main effect of age: F(1,17)?
Negative_regulation (decrease) of CA2-3
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.23
Consistent with the above, the administration with BMP-1 remarkably attenuated the neurobehavioral signs and neuronal loss in hippocampal CA1 and CA3 regions.
Negative_regulation (loss) of CA3 in neuronal
7) Confidence 0.26 Published 2006 Journal Eur J Nutr Section Body Doc Link 15997340 Disease Relevance 0 Pain Relevance 0
We found a substantial and highly significant loss of PV-interneurons in aged hippocampus (Fig. 4), with the CA2-3 region being the most affected (20% decrease for CA1, main effect of age: F(1,17)?
Negative_regulation (decrease) of CA2-3 in hippocampus associated with hippocampus
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.25
Although PV-neuron loss was observed in all regions of hippocampus, as well as prefrontal cortex, the most pronounced decrease was in CA2-3.
Negative_regulation (decrease) of CA2-3 in prefrontal associated with hippocampus
9) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.33 Pain Relevance 0.12
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Negative_regulation (positive) of CA3 in dentate gyrus associated with pyramidal cell, hippocampus and morphine
10) Confidence 0.24 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.93
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Negative_regulation (negative) of CA3 in hippocampus associated with hippocampus
11) Confidence 0.24 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.13 Pain Relevance 0.86
Based on these results we conclude that the majority of GluR2 loss is restricted to the dorsal hippocampus CA1 region and cortex layer III in the GluR2-cKO mice, with lesser loss in the dorsal CA3, and that expression levels are stable between 6 and 8 weeks of age in both genotypes in all five anatomical regions investigated.


Negative_regulation (loss) of CA3 in cortex associated with hippocampus
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.25
On the other hand, expression levels of calpastatin tended to be decreased in the cortex and CA3 of A?
Negative_regulation (decreased) of CA3 in cortex
13) Confidence 0.15 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.10 Pain Relevance 0
(C): Quantification revealed that infusion of FS-288 in KA-injected animals (n = 10, black bars) inhibited neurogenesis in the DG, CA3, and CA1, whereas infusion of activin A in KA-injected animals (n = 10, gray bars) had no effect on the number of new neurons compared to KA-injected controls (n = 11, white bars).
Negative_regulation (inhibited) of CA3 in bars associated with neurodegenerative disease
14) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.38 Pain Relevance 0.11
SK3 labeling is most prominent in the hilus and in the stratum lucidum of CA3.
Negative_regulation (lucidum) of CA3 in hilus
15) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.24
In adult rats, the number of astrocytes was shown to remain unchanged after traumatic brain injury in one study [31], while in another similar study, there was loss of GFAP reactivity in the ipsilateral CA3 region of the hippocampus 30 minutes after injury with progressive astrocyte loss over the next 24 hours [32].
Negative_regulation (loss) of CA3 in astrocytes associated with injury, hippocampus and brain injury
16) Confidence 0.10 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555560 Disease Relevance 0.93 Pain Relevance 0.05

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