INT128360

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
neutrophil 2
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 99.50 Very High Very High Very High
Inflammation 48 90.08 High High
Demyelination 12 88.52 High High
chemokine 78 83.60 Quite High
Inflammatory mediators 1 72.96 Quite High
Central nervous system 50 72.08 Quite High
Inflammatory response 1 69.20 Quite High
cINOD 1 55.52 Quite High
cytokine 9 25.00 Low Low
Spinal cord 8 20.44 Low Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 79 97.20 Very High Very High Very High
INFLAMMATION 51 90.08 High High
Demyelinating Disease 78 88.52 High High
Targeted Disruption 10 87.84 High High
Sprains And Strains 8 85.92 High High
Peritonitis 2 83.24 Quite High
Disease 19 82.64 Quite High
Immunization 5 79.60 Quite High
Infection 1 74.48 Quite High
Central Nervous System Disease 48 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, co-incubation of LTB4 (but not fMLP, TNF-alpha and MIP-1alpha) with SGE inhibited the ability of LTB4 to induce neutrophil migration in vivo and in vitro.
Negative_regulation (inhibited) of Positive_regulation (co-incubation) of MIP-1alpha in neutrophil
1) Confidence 0.41 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.46 Pain Relevance 0.17
CCR1 antagonist compounds were shown to inhibit CCL3 and CCL5 induced migration of MNCs in a dose dependent manner, and to reduce clinical EAE in rat [36-38].
Negative_regulation (inhibit) of Positive_regulation (induced) of CCL3 associated with multiple sclerosis and antagonist
2) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.39 Pain Relevance 0.37

General Comments

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