INT128361

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.74
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
joint 2
neutrophil 2
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 99 99.96 Very High Very High Very High
Inflammatory response 11 97.04 Very High Very High Very High
Inflammatory mediators 1 72.96 Quite High
antagonist 1 71.20 Quite High
Pain 3 56.08 Quite High
cINOD 17 55.52 Quite High
agonist 34 50.52 Quite High
COX2 2 50.00 Quite Low
cytokine 12 31.28 Quite Low
rheumatoid arthritis 2 25.44 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 121 99.96 Very High Very High Very High
Peritonitis 2 83.24 Quite High
Nociception 1 75.00 Quite High
Infection 1 74.48 Quite High
Arthritis 1 59.28 Quite High
Pain 3 56.08 Quite High
Cancer 136 50.00 Quite Low
Disease 10 26.40 Quite Low
Rheumatoid Arthritis 2 25.44 Quite Low
Inflammatory Bowel Disease 2 23.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of LTB4 induced by zymosan in the joint was reduced by the pretreatment with fucoidan or antineutrophil antibody as well as the production of PGE2 induced by LTB4.
Negative_regulation (reduced) of Positive_regulation (induced) of LTB4 in joint
1) Confidence 0.37 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.32 Pain Relevance 0.19
Moreover, co-incubation of LTB4 (but not fMLP, TNF-alpha and MIP-1alpha) with SGE inhibited the ability of LTB4 to induce neutrophil migration in vivo and in vitro.
Negative_regulation (inhibited) of Positive_regulation (co-incubation) of LTB4 in neutrophil
2) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.46 Pain Relevance 0.17
response to LTB4 was prolonged compared to WT mice, correlating with the
Negative_regulation (prolonged) of Positive_regulation (response) of LTB4
3) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.98 Pain Relevance 0.48
response to LTB4 was prolonged compared to WT mice, correlating with the
Negative_regulation (compared) of Positive_regulation (response) of LTB4
4) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.98 Pain Relevance 0.48

General Comments

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